Novel group of small molecules show promise against SARS-CoV-2 22 July 2021 | By Anna Begley (Drug Target Review) Researchers in Germany have identified 69 small molecules as binding partners for genomic RNA of SARS-CoV-2, possibly leading to new drugs.
Treg cells could be answer to multiple sclerosis treatments, say scientists 21 July 2021 | By Anna Begley (Drug Target Review) New research has shown that the protein Piezo 1 prevented Treg cells from controlling the effects of inflammation in a multiple sclerosis mouse model.
Metabolite could defend against harmful intestinal bacteria, study shows 21 July 2021 | By Anna Begley (Drug Target Review) Acetate was found to be involved in regulating complex microbes and could help trigger an immune response against harmful bacteria in mice.
Stem cell model demonstrates how COVID-19 infects brain cells 20 July 2021 | By Anna Begley (Drug Target Review) Researchers have developed a 3D “assembloid” that presents a potential entry route of COVID-19 into the brain.
Non-invasive optical method could provide insight into brain diseases 19 July 2021 | By Anna Begley (Drug Target Review) A non-invasive, label-free optical method can produce high-resolution imaging of cellular brain diseases in vivo.
High-quality, rapid technique developed for imaging in vivo 19 July 2021 | By Anna Begley (Drug Target Review) A US team has designed a high-quality, high-speed imaging system that could lead to new understandings of complex tissue specimens.
New spray shown to help heal heart attack damage in rats 15 July 2021 | By Anna Begley (Drug Target Review) A team have developed a minimally invasive exosome spray that helped repair rat hearts after myocardial infarction.
Metal-based molecule could inhibit build-up of Alzheimer’s peptides 15 July 2021 | By Anna Begley (Drug Target Review) UK researchers have created a metal-based molecule that inhibits the build-up of Alzheimer’s-associated peptide, amyloid-β, in lab tests.
Microcrystal electron diffraction could advance drug development 14 July 2021 | By Anna Begley (Drug Target Review) UK researchers have shown how microcrystal electron diffraction (MicroED) could obtain the structures of potential pharmaceuticals.
Prenatal editing halts progression of Hurler syndrome in pre-clinical model 14 July 2021 | By Anna Begley (Drug Target Review) US researchers used an AAV9 vector to edit a single base mutation in a prenatal mouse model, halting progression of Hurler syndrome.
Therapeutic target discovery could improve breast cancer treatments 14 July 2021 | By Anna Begley (Drug Target Review) Research by a team in Canada reveals a promising therapeutic target to counter HER2-positive breast cancer.
“Woman-controlled, on-demand” contraceptive product developed in US 13 July 2021 | By Anna Begley (Drug Target Review) US researchers have developed an antisperm monoclonal antibody that could become a safe and effective birth control method.
Screening method finds potential drugs to repurpose against COVID-19 13 July 2021 | By Anna Begley (Drug Target Review) Researchers have identified 38 drugs that could be repurposed to treat COVID-19 through a strategy involving virtual screening and cell-based assays.
Defective proteins found to be potential targets for Alzheimer’s treatments 12 July 2021 | By Anna Begley (Drug Target Review) US researchers have identified potential new treatment targets for Alzheimer’s disease, as well as existing drugs that could be used against these targets.
Newly designed tumour vaccine could prevent cancer recurrence 9 July 2021 | By Anna Begley (Drug Target Review) Scientists have used nanotechnology to develop personalised tumour vaccines which prevented cancer recurrence and metastasis challenges in mouse models.
