Methodology developed to genetically modify lab mice and human cells
A method designed to genetically alter laboratory mice can also be used to produce personalised animal models of an aggressive type of malignant brain cancer in children.
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Study reveals neuronal role in glioblastoma growth and how to prevent it
Researchers have discovered neurons send electrical signals to glioblastoma tumours, causing them to grow but have also identified methods of prevention in models.
New target for regulating mitochondria during stress identified
A new target has been identified for the treatment of heart failure, heart attack, stroke and neurodegeneration.
Automation of complex synthetic biological molecules enabled by robotics
A new platform combines AI, flow chemistry and robotics to minimise the need for human intervention in the synthesis process.
Vital cell metabolic pathway regulator identified by study
A study has revealed that the mitoNEET protein controls a metabolic and functional gateway on mitochondria, which could provide a drug target for cancer.
Study reveals how to make pancreatic cancer chemotherapy more effective
Researchers have shown that blocking a particular enzyme causes chemotherapy to become more effective against pancreatic cancers in pre-clinical studies.
CRISPR used to treat Duchenne muscular dystrophy in mice
A study has shown that CRISPR can be used as a regenerative technique to treat Duchenne muscular dystrophy, which could be developed as a therapeutic option for humans.
New technology developed to screen for Huntington’s treatments
Researchers have created a new technology which enabled them to discover more about the causes of Huntington’s disease and which can be used to test drugs.
Short peptides discovery could lead to new treatments for Alzheimer’s
The memory of mice with Alzheimer's greatly improved after they were injected with two newly discovered short peptides.
New mechanism of controlling fat production revealed
A new study has shown a new mechanism of controlling fat production in the body which could lead to new therapies to treat obesity.
Mutant form of Ebola could be used in vaccine development
A study has shown that a mutated form of the Ebola virus protects macaque models against the disease, demonstrating an opportunity for a drug target.
Researchers explain how lymphoma cells metastasise to the brain
Chronic inflammatory processes in ageing brains lead to lymphoma cells that have entered the brain tissue being retained.
Transplanted brain stem cells survive without anti-rejection drugs in mice
An experiment with mice has successively blocked the immune system's T cells from killing transplanted cells.
Protein vital for enterovirus replication identified by study
Researchers have discovered a particular protein that is required for enterovirus replication and survival, presenting a therapeutic target.
Protein target for diabetes-related Alzheimer’s identified
A study has found a protein which, when depleted, resulted in Alzheimer’s disease symptoms appearing in mouse and brain tissue models.
