Scientists develop a new way to fight late-stage sepsis
Scientists have used nanotechnology to transform healthy immune cells into a drug with enhanced power to kill bacteria to help the immune system fight sepsis.
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Deleting body clock regulator gene BMAL1 protects mice against bacterial pneumonia
Deletion of the BMAL1 gene causes changes to the macrophage cytoskeleton, enhancing mouse model ability to combat bacterial pneumonia infection, according to new research.
ELRIG and British Pharmacological Society enter collaborative alliance
The two organisations have entered into a two-year alliance to improve scientific exchange in the drug discovery industry.
Syndecan-4 cell sensory protrusions activate hallmarks of cancer
A study has revealed that activation of syndecan-4 sensory protrusions extending from cells may be a future target for cancer therapy.
Antibody HIV therapy for primate newborns shows potential as therapy
A study has shown that administering two antibodies soon after birth can prevent HIV from developing in rhesus macaques.
Computational model of molecular interactions could improve new medicine development
Researchers have produced a mathematical framework enabling quick assessment of how different parameters control interactions between molecules with multiple binding sites.
Bile acids acting as inflammation regulators may protect against IBD
Research has found that bile acids, converted by gut microbes, act as inflammatory regulators in IBD by modulating the differentiation of T cells in the gut.
Study identifies molecules to potentially treat Plasmodium parasites
Researchers have discovered the most effective molecules to target DNA methylation from Plasmodium parasites, having shown success in pre-clinical trials.
RNA-targeting strategy can block Parkinson’s disease driver
A new drug-like compound has been developed which reportedly prevents the body from producing a protein that is often at the root of Parkinson's disease.
Combination of antibodies could improve cancer immunotherapies
A study has shown that using three antibodies with two different mechanisms of action could be a novel way to improve immuno-oncology treatments.
Activating c-Cbl gene causes immune system to attack cancer cells
Upregulation of the c-Cbl gene causes degradation of the immune checkpoint protein PD-1 and may provide a possible new avenue for cancer therapies, according to researchers.
Alzheimer’s vaccine shows promising results in bigenic mice
Researchers have created a new combination vaccine therapy that can induce strong immune responses against tau and Aβ pathologies seen in Alzheimer’s in bigenic mice.
Short chain fatty acid supplementation could improve stroke recovery
Researchers have found that supplementing drinking water with short chain fatty acids helped mice to recover from stroke by increasing microglia activity.
Researchers image C. diff toxins to aid in drug design
A new study has used several imaging techniques to characterise C. diff toxins, which could help to design drugs to combat infections from the bacteria.
Organoid models for personalised treatments of glioblastomas developed
Lab-grown brain organoids from patients’ glioblastomas could be useful models to rapidly test and identify effective personalised treatments, find researchers.
