Stem cell-based vaccine protects mice against pancreatic cancer

Research by scientists at Stanford University, US, has advanced an old concept to develop a new strategy to train the immune system of mice to recognise cancer cells. This work is based on the recent understanding that induced pluripotent stem cells (iPSCs) produce a large set of antigens that have overlap to a specific type of pancreatic cancer and that these similarities can be used for potential clinical benefit.

According to the team, tumour cells often contain unique antigens that are rare or not found in other tissues of the body and like antigens from a virus, can be targets for the immune system. To date, it has been a challenge to develop an effective and durable vaccine against tumours.

In this study, the researchers capitalised on the knowledge that iPSCs produce antigens that are also found on different types of tumours, but not present in most normal tissue. They then vaccinated mice with the iPSCs that were treated with irradiation so that they would not divide and a CpG adjuvant to stimulate a robust immune response. Their hope was to train the mice’s immune systems to mount a response against the iPSCs, or any type of cell with a similar antigen makeup, including cancer cells.

The team found that the iPSC vaccination protected 75 percent of mice subsequently injected with pancreatic cancer cells from developing tumours. Furthermore, vaccination increased the number of tumour-targeting immune cells and the vaccinated mice developed antibodies against the cancer cells.

As this iPSC-based vaccine targets many cancer antigens simultaneously, this vaccination approach may be more durable as tumour cells may be left with fewer ways of escaping recognition by the vaccine-trained immune system. This strategy may also work for other cancer types with similar antigen makeup to iPSCs.

The researchers say that further studies are now required to show if iPSC cancer vaccines are safe and effective in patients, both in preventing tumour growth or re-growth and in eliminating established tumours.

The study was published in Stem Cell Reports.