Immunocore and Lilly announce immunotherapy-based clinical trial collaboration in melanoma

Posted: 29 June 2015 | Victoria White

Immunocore and Lilly have entered into a collaboration to explore the utility of IMCgp100 in combination with galunisertib and merestinib in melanoma…

Immunocore and Lilly have entered into an immunotherapy based clinical trial collaboration to explore the utility of Immunocore’s IMCgp100 in combination with Lilly’s galunisertib and merestinib for the treatment of melanoma.

The goal of the collaboration is to identify combination regimens that provide synergies in efficacy and durability in patients with metastatic cutaneous and uveal melanomas.

Under the terms of the agreement, Immunocore and Lilly will conduct a Phase Ib/II clinical study evaluating the safety and preliminary efficacy of IMCgp100 in combination with galunisertib in metastatic cutaneous melanoma. A second Phase Ib/II study will be conducted combining IMCgp100 with merestinib in metastatic uveal melanoma. These studies are anticipated to begin in 2016.

IMCgp100 and galunisertib are members of a new class of cancer treatments known as immunotherapies, which are designed to enhance the body’s own immune system in fighting cancer and whose mechanisms of action have the potential to be complementary. IMCgp100 is Immunocore’s most advanced Immune mobilising mTCR Against Cancer molecules (ImmTAC), which are a novel class of bi-specific biologic drugs based on T-cell receptors (TCRs) with ultra-high affinity for intracellular and extracellular cancer targets. Lilly’s galunisertib is a small molecule inhibitor of TGF beta R1 kinase that in vitro selectively blocks TGF beta signalling. TGF beta promotes tumour growth, suppresses the immune system and increases the ability of tumours to spread in the body. Merestinib is Lilly’s small molecule multi-kinase inhibitor that in vitro selectively blocks signalling of MET, MST1R (RON), AXL, and MKNK1/2.

Combining IMCgp100 with galunisertib and merestinib has the potential to transform melanoma treatment

“This collaboration with Immunocore underscores Lilly’s commitment to discovering the potential of combination therapies, which will be key to the future of cancer care for people fighting diseases such as melanoma,” said Richard Gaynor, M.D., senior vice president, product development and medical affairs for Lilly Oncology. “Lilly is building a robust portfolio of potential advances in immunotherapy through our own research as well as with strategic collaborations like Immunocore.”

Immunocore and Lilly entered into a co-discovery and co-development collaboration, announced in July 2014, to research and potentially develop other novel T-cell-based cancer therapies built on Immunocore’s ImmTAC platform.

“We are very pleased to be able to announce a second collaboration with Lilly after entering into a collaboration last year,” said Eliot Forster, Chief Executive Officer of Immunocore. “Combining our ImmTAC, IMCgp100 with Lilly’s galunisertib and merestinib has the potential to transform the treatment of metastatic cutaneous and uveal melanoma. Immunocore is committed to the development of IMCgp100 in metastatic uveal and cutaneous melanoma where there is such great unmet medical need.”

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