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Stem Cells

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CRISPR tagging used to grow neuronal cells from stem cells

3 December 2020 | By Victoria Rees (Drug Target Review)

A new technique using CRISPR has been developed by researchers to identify programmed stem cells that mature into neuronal cells.

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Transcription factor source for customised stem cell programming

1 December 2020 | By Hannah Balfour (Drug Target Review)

Researchers have found a way to systematically extract various cell types from induced pluripotent stem cells and made their transcription factor source accessible for other scientists.

article

Development of a physiologically relevant lung model for understanding SARS-CoV-2 infection

27 November 2020 | By Professor Lyle Armstrong (Newcastle University and Newcells Biotech)

COVID-19 is known to infect the lungs; however, the dynamics of viral infection and replication are poorly understood. Alongside the Liverpool School of Tropical Medicine, Professor Lyle Armstrong and colleagues have been working to develop a human lung epithelium model of SARS-CoV-2 infection and replication. In this article, he describes…

article

Drug Target Review – Issue 4 2020

26 November 2020 | By Drug Target Review

In this journal, find articles discussing antimicrobial resistance, exploring why inhibiting the interaction between SARS-CoV-2 and neuropilin-1 could help combat COVID-19, as well as how CRISPR can be used to enhance productivity in cell line development. Also in this issue, features on engineering new biologic drugs and precision medicine.

alveoli with blue SARS-CoV-2 particles (spiky balls) inside

news

Mini lung organoids replicate COVID-19 pathology in a dish

20 November 2020 | By Hannah Balfour (Drug Target Review)

Scientists developed a new culture technique for alveolospheres which they used to study how alveolar cells respond to SARS-CoV-2 infection.

news

New 3D cell culture method could enable personalised cancer therapies

13 November 2020 | By Victoria Rees (Drug Target Review)

A team has extracted single tumour cells from existing cell lines to create 3D cell cultures that could allow for personalised cancer therapies.

Cell culture plates with orange growth media and a pipette above

news

Cell line development services market to grow at 13.3 percent

12 November 2020 | By Hannah Balfour (Drug Target Review)

Reports suggest the market growth is driven by advances in biotechnology and its applications, as well as COVID-19 research.

news

New bioprocess generates haematopoietic stem and progenitor cells

10 November 2020 | By Victoria Rees (Drug Target Review)

A new single-use, closed-system upstream bioprocess has been developed which enables the production of large number of haematopoietic stem cells and progenitor cells.

news

Midbrain organoids developed for automated chemical screening

5 November 2020 | By Victoria Rees (Drug Target Review)

Researchers have used small molecule neural precursor cells to develop midbrain organoids that enable drug effects to be assessed in a complex cell environment.

news

Scientists identify new way to target leukaemia cells

28 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have found they can make leukaemia cells vulnerable by dislodging leukaemia stem cells from a tumour-promoting niche.

whitepaper

ebook: Phenotypic screening with iPSC-derived cardiomyocytes and neurons

27 October 2020 | By Molecular Devices

Identify therapeutic effects and adverse responses to compounds earlier in the drug discovery process.

news

Flow cytometry market to exhibit CAGR of 12 percent

23 October 2020 | By Victoria Rees (Drug Target Review)

A new report has said that by 2023, the flow cytometry market will be worth $8.88 billion, partly due to an increase in stem cell research.

video

Video: Gain deeper insights into cellular 3D structures with water immersion objectives

13 October 2020 | By Molecular Devices

Water immersion objectives are essential for capturing more data at greater depths in 3D structures, such as spheroids and thick tissues.

colourful SARS-CoV-2 particles surrounding a body shape with the lungs drawn in red

news

The NF-κB pathway drives fatal inflammation in COVID-19, say scientists

2 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers found that the SARS-CoV-2 infection activates the NF-κB pathway, driving unchecked inflammation that contributes to total organ failure in COVID-19 patients.

stem cell culture stored in liquid nitrogen

news

Regulating cell plasticity through CDK8 inhibition

29 September 2020 | By Hannah Balfour (Drug Target Review)

Researchers show CDK8 inhibition reduces cell plasticity without damaging cells and suggest their approach could have implications for autoimmunity and oncology.

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Stem Cells