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Atg2 tethers pre-autophagosomal membranes to endoplasmic reticulum
Researchers at Tokyo University have investigated the role of the Atg2 protein in the process of autophagy to aid drug discovery into neurodegeneration...
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Single molecule fluorosequencing to transform biological research
Single molecule fluorosequencing could revolutionise the way researchers analyse disease, with the method enabling the investigation of single cells...
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Application note: Orthogonal approaches for studying bacterial biofilms using photometric detection
This application note aims to demonstrate the benefits of using orthogonal approaches for studying Staphylococcus aureus biofilms—in particular, their susceptibility to antimicrobial agents...
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Investigating tumour microenvironments for more effective treatments
Tumour microenvironments give insights into more effective therapies against lung cancer, a bigger killer than colon, prostrate and breast cancers combined...
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RNA circuits making gene therapy more effective
Circuits consisting of single-stranded RNA have been shown to be make gene therapy more effective, and allows precise control over the therapy...
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Lassa fever vaccine reveals new test for immunity
A Lassa fever vaccine offers researchers a different way to test for protection, which could aid the development of more potent vaccines...
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Vaccine offers complete protection against Ebola virus
Researchers at The Wistar Institute have developed a DNA based vaccine that has offered compete protection against the Ebola virus in preclinical trials...
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Scientists find treatment for tumour cell population that causes tumour relapse
Researchers in Europe have developed a treatment that targets a tumour cell population responsible for therapy resistance and tumour relapse, giving optimism for patients with the most frequent form of cancer.
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Elrig 2018: Drug discovery using small and large molecules
The Drug Target Review team are at Elrig Drug Discovery 2018 in the London ExCel...
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Biodegradable devices speed up nerve regeneration
Researchers have developed an implantable and biodegradable device to aid the regeneration of nerve after damage from accidents and sports injuries...
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Scientists create map of brain region linked to Alzheimer’s disease
Scientists have mapped areas of the brain that are linked to Alzheimer's disease to deliver genetically-targeted drugs to specific neurons...
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Efficacy of PET imaging in managing chronic liver diseases
PET imaging could be used as a non-invasive substitute to painful and complicated liver biopsies for chronic liver disease...
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RNA-seq of 20,000 cardiac cells reveals heart disease insights
RNA analysis of 20,000 cardiac cells from heart tissue in both ordinary and deceased mice showed an insight to the development of heart disease...
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Application note: Increasing throughput with dual emission AlphaLISA-AlphaPlex assay and simultaneous dual emission detection
Multiplexing AlphaLISA type assays will increase throughput while sample expenditure and costs are minimised. The ability of the PHERAstar FS microplate reader to perform simultaneous dual emission detection of this assay will allow users to double the information obtained from each well in the same amount of time as needed…
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Chemotherapy and APOE4 linked to cognitive issues
Both human and mouse models show that chemotherapy and APOE4 are linked to cognitive issues faced by patients who overcome cancer...
