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Conformational equilibria in GPCRs provides clues about activation

23 March 2021 | By Victoria Rees (Drug Target Review)

Having revealed the activation mechanism and functional states of A2AR signalling, a GPCR, researchers say this could aid drug discovery.

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Catalogue: Nuclease-Free tubes, tips & buffers

22 March 2021 | By Thermo Fisher Scientfic

Working with RNA requires rigorous nuclease contamination controls in place. Stock up on Nuclease-Free tubes tips and buffers #Back2Lab

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Spike protein analysis explains faster spread of SARS-CoV-2 variants

18 March 2021 | By Victoria Rees (Drug Target Review)

Using cryo-electron microscopy, researchers have imaged how the SARS-CoV-2 Spike protein changes with the D614G mutation to enable faster spread of infection.

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Movement of nanorobots observed in vivo using PET

18 March 2021 | By Victoria Rees (Drug Target Review)

A large number of nanorobots in the bladders of mice have been visualised to reveal their movement and behaviour.

Dynabeads Viral Enrichment Feature Image

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Brochure: Dynabeads manual and automated SARS-CoV-2 enrichment

18 March 2021 | By Thermo Fisher Scientific

Achieve intact SARS-CoV-2 virus enrichment products. You only need a centrifuge, and the intact virus is enriched in less than 3 hours with very little hands-on time.

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Nanolitre‐scale cell assays developed with droplet microarray-mass spec

16 March 2021 | By Victoria Rees (Drug Target Review)

A team has developed nanolitre cell assays on droplet microarrays to enable pharmacodynamic monitoring in live cells.

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Novel deep learning tool developed to analyse microscopy images

16 March 2021 | By Victoria Rees (Drug Target Review)

An artificial intelligence platform has been created to enable tens of thousands of microscopy images to be generated in an hour.

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Catalogue: KingFisher APEX is the pinnacle of automated extraction

16 March 2021 | By Thermo Fisher Scientfic

KingFisher APEX is our newest instrument for automation workflows for high throughput DNA and RNA extraction. With precision handling and touch screen interface.

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Researchers reveal how key enzyme APT2 works in cells

15 March 2021 | By Victoria Rees (Drug Target Review)

Using X-ray crystallography and simulations, researchers have shown that APT2 is a hybrid between a lipid carrier protein and a hydrolase.

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Researchers reveal 3D structure responsible for gene expression

12 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have produced the first 3D image of the Mediator-bound pre-initiation complex, key in the regulation of gene expression.

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Team improves non-invasive visualisation of photoreceptors in eye

12 March 2021 | By Victoria Rees (Drug Target Review)

A new imaging technique for photoreceptors has been developed by selectively blocking light used to observe the eye.

whitepaper

Catalogue: Ribosomal RNA from bacteria with RiboMinus

10 March 2021 | By Thermo Fisher Scientfic

RiboMinus Bacteria 2.0 Transcriptome Isolation Kits perform efficient transcriptome enrichment from total bacterial RNA. Improve your RNA extraction from bacteria today.

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Novel spectroscopic microscope images biological molecular conformations

9 March 2021 | By Victoria Rees (Drug Target Review)

A spectroscopic microscope has been developed by researchers to gather data on biological conformations faster and more accurately.

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Structure of protein that triggers neurodegeneration isolated and analysed

4 March 2021 | By Victoria Rees (Drug Target Review)

Using X-ray crystallography and cryo-electron microscopy, researchers have elucidated the structure of the SARM1 protein, a target for neurodegeneration.

news

Atomic force microscopy used to study endonuclease digestion of DNA nanostructures

2 March 2021 | By Victoria Rees (Drug Target Review)

A team of researchers have used microscopy techniques to monitor DNA degradation and anticancer drug release from nanostructures.

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