webinar Novel small molecule inhibitors of oncogenic SHP2 variants characterised by cellular target engagement 28 January 2021 | By Eurofins DiscoverX & Sanford Burnham Prebys Discovery In this on-demand webinar industry experts discuss how the InCELL Pulse technology provides a valuable tool for the discovery and characterisation of novel SHP2 inhibitors.
news New database could inform the development of treatments to slow ageing 27 January 2021 | By Hannah Balfour (Drug Target Review) The database could save substantial resources for those wanting to do pre-clinical studies of interventions for age-related diseases, said scientists.
news Novel compound named BC1618 could serve as new diabetes drug 27 January 2021 | By Victoria Rees (Drug Target Review) Researchers have identified a new compound that improved responses to insulin and treated diabetes in obese mouse models.
news Attenuated vaccine could combat fatal Leptospira bacteria 27 January 2021 | By Hannah Balfour (Drug Target Review) A single vaccination with a mutated Leptospira bacteria prevented rodent models from developing leptospirosis, the most fatal type of zoonotic disease worldwide.
news Novel antibody candidate could offer pan-coronavirus protection 26 January 2021 | By Hannah Balfour (Drug Target Review) The lead candidate, ADG2, was able to neutralise SARS-CoV and various strains of SARS-CoV-2, including those that are resistant to currently available antibody treatments.
whitepaper Case study: Identifying allosteric modulators for GPCRs 25 January 2021 | By Eurofins Discovery Identifying allosteric modulators and biased agonists for clinically relevant GPCRs. Case Studies using Eurofins Discovery’s GPCR product solutions.
news Could synNotch CAR T cells be the answer to fighting solid tumours? 22 January 2021 | By Hannah Balfour (Drug Target Review) Researchers have developed a novel CAR T-cell therapy for neuroblastoma which uses gating to limit toxicity and T-cell exhaustion.
news Novel target could improve the efficacy of treatments for renal cell carcinoma 21 January 2021 | By Hannah Balfour (Drug Target Review) A new study shows that upregulating the activity of the ACE2 signalling pathway in kidney cancer cells enhances the effects of clinically used treatments.
news Novel nanobody combinations protect cells from SARS-CoV-2 in vitro 14 January 2021 | By Hannah Balfour (Drug Target Review) By combining nanobodies targeting different regions of the SARS-CoV-2 Spike protein, researchers were able to protect cells from infection.
news 2B7 antibody could be the breakthrough needed for dengue fever therapies 8 January 2021 | By Hannah Balfour (Drug Target Review) Scientists show that an antibody targeting a protein acting as a viral toxin, can prevent the dengue virus from infecting human cells.
news Inhibiting acetate metabolism shows promise in breast cancer model 8 January 2021 | By Hannah Balfour (Drug Target Review) Inhibiting the ACSS2 enzyme with a molecule called VY-3-135 caused a significant reduction in the growth of breast cancer tumours in vivo.
news Bioactive compound in ginger could be used in treatment of lupus 7 January 2021 | By Victoria Rees (Drug Target Review) According to new research, the bioactive compound of ginger root, 6-gingerol, prevented disease progression of lupus in mice.
whitepaper Whitepaper: Virus vaccine research – accelerated workflows 7 January 2021 | By PerkinElmer Discover how workflows are being accelerated to speed up the vaccine research and development process while maintaining safety and immunogenicity.
news Novel bronchodilator could be used for control of asthma 5 January 2021 | By Hannah Balfour (Drug Target Review) Study identifies a promising new compound that can open constricted airways and could be a promising treatment for obstructive lung diseases.
news Drug screening reveals pralatrexate could be repurposed to treat COVID-19 4 January 2021 | By Victoria Rees (Drug Target Review) Computational drug screening has shown that chemotherapy drug pralatrexate could potentially be repurposed to treat COVID-19.
![A microscopy image of Leptospira bacteria [Credit: Wunder et al. (CC BY 4.0)].](https://drug.russellpublishing.co.uk/wp-content/uploads/Leptospira-bacteria.jpg)
