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Novartis and UC Berkeley collaborate to tackle ‘undruggable’ disease targets
Collaboration aims to unlock difficult drug targets and accelerate the discovery of new medicines in areas such as infectious diseases and cancer...
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CYC065-eribulin combination therapy for triple-negative breast cancer identified
Researchers find novel combination disrupts multiple factors in aggressive breast cancer...
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Potential therapeutic protein inhibitors for Chagas disease
Researchers have used a multi-modal integrated approach to develop potential new anti-Chagas therapies...
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Bryostatin-1 shows early promise for dormant HIV infection
Scientists have designed a synthetic molecule bryostatin-1 that can reactivate dormant HIV...
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A fat-regulating enzyme could hold the key to diabetes and cancer
Researchers shed light on a key fat-regulating enzyme's role in diabetes and cancer...
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Structure based drug discovery facilitated by crystallography
Drugs exert therapeutically meaningful effects if they bind with appropriate selectively and potency to their respective targets. Although many of the assay techniques employed in early-stage drug discovery provide evidence that a drug is acting upon the target under investigation, this is often indirect and the site of action and…
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Antibiotic identified that reduces infection risk in young leukaemia patients
Researchers have identified an antibiotic that significantly reduced the odds of infections in children starting treatment for ALL without an apparent increase in antibiotic resistance...
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Magnetic cellular ‘Legos’ for the regenerative medicine of the future
By incorporating magnetic nanoparticles in cells researchers have succeeded in creating cellular magnetic "Legos."...
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Venomous compounds may lead to better skin treatments
Compounds derived from fire ant venom can reduce skin thickening and inflammation in psoriasis...
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DNA sequencing could open up new drug indications for rare cancers
A network of hospitals have systematically collected biopsies from metastatic cancer patients in order to create a global database...
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How receptors for medicines work inside cells
G protein-coupled receptors are the key target of a large number of drugs, scientists have now been able to show more precisely how these receptors act in the cell interior...
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Drug Target Review – Issue #3 2017
Included in this issue: The importance of industry partnerships; Calcilytics as potential novel therapeutic treatments to halt Alzheimer's disease; Accelerating neuroscience research with flow cytometry...
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Chemo-boosting drug discovered for leukaemia
Drugs developed to treat heart and blood vessel problems could be used to treat leukaemia...
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CRISPR gives new insight into autoimmune disorders
Researchers have used a modified version of the gene-editing technique CRISPR in search for gene activators...
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Nanoparticles give disease-fighting properties to cells
A new biomedical tool has been developed using nanoparticles that deliver transient gene changes to targeted cells...
