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Novartis and UC Berkeley collaborate to tackle ‘undruggable’ disease targets

28 September 2017 | By Dr Zara Kassam (Drug Target Review)

Collaboration aims to unlock difficult drug targets and accelerate the discovery of new medicines in areas such as infectious diseases and cancer...

news

CYC065-eribulin combination therapy for triple-negative breast cancer identified

27 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers find novel combination disrupts multiple factors in aggressive breast cancer...

news

Potential therapeutic protein inhibitors for Chagas disease

26 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used a multi-modal integrated approach to develop potential new anti-Chagas therapies...

news

Bryostatin-1 shows early promise for dormant HIV infection

22 September 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have designed a synthetic molecule bryostatin-1 that can reactivate dormant HIV...

news

A fat-regulating enzyme could hold the key to diabetes and cancer

18 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers shed light on a key fat-regulating enzyme's role in diabetes and cancer...

article

Structure based drug discovery facilitated by crystallography

15 September 2017 | By Dr Sheraz Gul, Dr Sophie Zimmermann

Drugs exert therapeutically meaningful effects if they bind with appropriate selectively and potency to their respective targets. Although many of the assay techniques employed in early-stage drug discovery provide evidence that a drug is acting upon the target under investigation, this is often indirect and the site of action and…

news

Antibiotic identified that reduces infection risk in young leukaemia patients

15 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified an antibiotic that significantly reduced the odds of infections in children starting treatment for ALL without an apparent increase in antibiotic resistance...

news

Magnetic cellular ‘Legos’ for the regenerative medicine of the future

13 September 2017 | By Dr Zara Kassam (Drug Target Review)

By incorporating magnetic nanoparticles in cells researchers have succeeded in creating cellular magnetic "Legos."...

news

Venomous compounds may lead to better skin treatments

11 September 2017 | By Dr Zara Kassam (Drug Target Review)

Compounds derived from fire ant venom can reduce skin thickening and inflammation in psoriasis...

news

DNA sequencing could open up new drug indications for rare cancers

8 September 2017 | By Dr Zara Kassam (Drug Target Review)

A network of hospitals have systematically collected biopsies from metastatic cancer patients in order to create a global database...

news

How receptors for medicines work inside cells

6 September 2017 | By Dr Zara Kassam (Drug Target Review)

G protein-coupled receptors are the key target of a large number of drugs, scientists have now been able to show more precisely how these receptors act in the cell interior...

article

Drug Target Review – Issue #3 2017

6 September 2017 | By Drug Target Review

Included in this issue: The importance of industry partnerships; Calcilytics as potential novel therapeutic treatments to halt Alzheimer's disease; Accelerating neuroscience research with flow cytometry...

news

Chemo-boosting drug discovered for leukaemia

4 September 2017 | By Dr Zara Kassam (Drug Target Review)

Drugs developed to treat heart and blood vessel problems could be used to treat leukaemia...

news

CRISPR gives new insight into autoimmune disorders

1 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used a modified version of the gene-editing technique CRISPR in search for gene activators...

news

Nanoparticles give disease-fighting properties to cells

30 August 2017 | By Dr Zara Kassam (Drug Target Review)

A new biomedical tool has been developed using nanoparticles that deliver transient gene changes to targeted cells...

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