news
GalNAc-T6 enzyme selectively up-regulated in colon adenocarcinomas
Researchers have identified an enzyme that appears to drive the conversion of normal colon tissue into cancer...
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DRD2 crystal structure provides antipsychotic drug development tool
Crystal structure of the dopamine 2 receptor bound to an antipsychotic drug provides a much-needed discovery in the quest to create effective drugs with fewer side effects...
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Elimination of c-Raf kinase induces regression of advanced lung tumours
A study has shown how the elimination of the c-Raf kinase by genetic manipulation causes the regression of Kras oncogene-driven advanced lung tumours...
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HIF-1 protein shows promise as a non-hormonal treatment for menorrhagia
Researchers have identified a key protein that could explain why heavy bleeding occurs during menorrhagia, paving the way for potential treatments that avoid the need to take hormones...
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HIV-1 genetic diversity is higher in vaginal tract than in blood during early infection
New evidence supports the existence of genetic 'sieve' on the path from vaginal tract to bloodstream...
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G-CSF protein involved in cocaine addiction
Researchers have identified a protein produced by the immune system that could be responsible for the development of cocaine addiction...
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Blood-vessel-on-a-chip provides insight into new anti-inflammatory drug candidate
Researchers have discovered that synthetic APC-mimicking molecules provide anti-inflammatory and anti-thrombotic protection to endothelial cells without interfering with blood clotting...
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Hear from Janssen and Antikor Biopharma at SMi’s ADC Conference, April 2018
SMi's ADC conference will be bringing a global presence from Pfizer, Genentech, Ablynx, Spirogen, Seattle Genetics, Medimmune, Antikor Biopharma, Heidelberg Pharma and more...
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Researchers use AI technology to chart immune cell receptor
Johns Hopkins scientists have used a form of artificial intelligence to create a map that compares types of cellular receptors, the chemical ‘antennas’ on the surface of immune system T-cells.
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Anti-obesity drug shrinks fat without suppressing appetite
Researchers have discovered a drug that has been shown to selectively shrink excess fat by increasing fat cell metabolism...
article
Rational drug design: How far have we come?
From the early use of Hansch parameters and Topliss Trees to today’s computational structure–activity techniques, medicinal chemists have long sought to rationalise drug design to find the quickest and most resource-efficient route to market. But while modern strategies are more reliant on statistical algorithms and vast data libraries, these founding…
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Organ-on-a-chip device successfully models heart disease
A new device that models atherosclerosis can help researchers better understand the disease, develop therapies and diagnose blood health...
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Expert view: Conquering late stage failures with advanced hit-to-lead techniques
Failing early in drug discovery is the primary driving force for new techniques in the hit-to-lead phase.
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Identification of hits and leads for human African trypanosomiasis
Neglected tropical diseases (NTD) affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. This article reviews some of these compounds...
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Expert view: Optimising the hit-to-lead workflow
Hits identified in high-throughput screens are evaluated within the hit-to-lead phase of drug discovery, where they undergo an iterative optimisation process employing a variety of techniques to identify promising lead compounds to move forward to the lead optimisation phase.
