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The mysterious functions of the PCSK9 protein

3 January 2019 | By Drug Target Review

Researchers have described the methods used to build a model of the 'druggable' PCSK9 inhibitor and detailed how it works...

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Potential drug targets found by muting large silent genes

2 January 2019 | By Iqra Farooq (Drug Target Review)

Streptomyces bacteria has been used to identify compounds that could lead to the production of drugs to treat various conditions...

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Human antibody discovery could save lives from fungal killer

12 December 2018 | By Drug Target Review

Novel therapy uses antibodies cloned from patients who have recovered from an infection caused by the fungus Candida…

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Compounds in coffee may fight Parkinson’s

11 December 2018 | By Drug Target Review

Caffeine plus another compound in coffee beans' waxy coating may protect against brain degeneration...

Harmonizing drug-target binding data analytics on a single platform

article

Webinar highlights: Harmonising drug-target binding data analytics on a single platform

7 December 2018 | By PerkinElmer

Harmonising drug-target binding data analytics looks at building a single, integrated software platform for a future pharma research and development digital ecosystem. This webinar, sponsored by PerkinElmer, outlined the fundamentals of a design process where an experimental analytics data workflow was integrated into a more seamlessly interactive digital platform.

article

Expert view: Challenges in drug discovery screening

6 December 2018 | By Steven Jarvis (Scientific Director - Global Strategic Accounts at Merck)

The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.

article

PAINS management: an open source model to eliminate nuisance compounds

4 December 2018 | By Stephen J. Capuzzi and David C. Morris (Eshelman School of Pharmacy - University of North Carolina Chapel Hill)

High-throughput screening (HTS) technologies have enabled the routine testing of millions of compounds towards the identification of novel ‘hit’ molecules for therapeutic targets. Oftentimes in this drug discovery process, however, compounds that show promising activity in primary screens show no activity during subsequent hit qualification or progression efforts.

article

Application Notes supplement 2018

4 December 2018 | By Drug Target Review

Researchers are always looking more effective and efficient ways of making their work more successful. In this supplement, some of our commercial partners share their data, detailing the application of their technology.

article

Hit-to-Lead In-Depth Focus 2018

4 December 2018 | By Drug Target Review

This In-Depth Focus examines our understanding of the comprehensive and complex innate immune system, to develop novel treatments and an open source model to eliminate nuisance compounds

article

Targeting innate immunity to treat disease: potential therapeutic applications

3 December 2018 | By Christopher Schaber - PhD, Oreola Donini - PhD - Chief Scientific Officer, President - Chief Executive Officer, Richard Straube - MD - Chief Medical Officer

Despite being one of the more ancient aspects of immunity, therapeutic modulation of the innate immune system has rarely been attempted. Innate immunity is intrinsically linked to the generation of inflammation – necessary for signalling to the adaptive immune system but often self-perpetuating and over-exaggerated, leading to deleterious effects, including…

whitepaper

Application note: Direct measurements of cellular metabolism for identification of mitochondrial drug targets

29 November 2018 | By Brian P. Dranka, George W. Rogers, Sarah E. Burroughs

Drug target identification has a key role in the drug discovery value chain. A critical step in the development of pharmaceuticals is identifying the direct targets of potential drug candidates as well as distinguishing any secondary or off-target effects...

news

Technique to identify small molecules could speed up drug discovery

29 November 2018 | By Drug Target Review

UCLA-led research has shown how using electron microscopes to analyse small molecules coud be beneficial in speeding up the drug discovery process...

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Vaccine signatures point to a better understanding of infectious diseases

29 November 2018 | By Drug Target Review

Researchers have developed a comprehensive way to evaluate how immune responses of humanised mice measure up to actual humans...

news

Stimulating fibroblasts can trigger hair growth in wound healing

28 November 2018 | By Dr Zara Kassam (Drug Target Review)

Stimulating fibroblasts through the sonic hedgehog pathway can trigger hair growth not previously seen in wound healing...

news

slincR gene could shed light on chemical exposure effects in humans

26 November 2018 | By Drug Target Review

The discovery of a new gene in zebrafish could lead to a better understanding of how exposure to chemicals leads to disease in humans...

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