Robert Skolik (University of Louisville)

article

Making cell culture models more physiologically relevant

22 June 2021 | By Robert Skolik (University of Louisville)

A major limitation in drug development is the occurrence of drug-candidate toxicity during clinical research. This may occur because tumour-derived cell lines are limited as a pre-clinical model – in part because of an altered metabolic poise. A recent study has revealed a profound plasticity in gene expression and metabolic poise that can…

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Robert Skolik (University of Louisville)

Making cell culture models more physiologically relevant