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27 November 2018 | By Douglas B. Kell (School of Chemistry - The Manchester Institute of Biotechnology), Marina Wright Muelas (School of Chemistry - The Manchester Institute of Biotechnology), Philip J. Day (The Manchester Institute of Biotechnology & Faculty of Biology - Medicine and Health - The University of Manchester), Steve O’Hagan (School of Chemistry - The Manchester Institute of Biotechnology)
The relative failure of molecular target-based drug discovery has led to a return to phenotypic screening. Targets that are intracellular necessitate their drug ligands to pass through plasma membranes, where the protein:lipid ratio is often 3:1 by mass and at least 1:1 by area. The widespread view that most of…
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