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Mandy Parrett (Drug Target Review)

GABA possible treatment avenue of type 2 diabetes

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Promising new avenue to tackle obesity-related diabetes

2 July 2021 | By Mandy Parrett (Drug Target Review)

New findings from collaborative research in the United States have identified a promising new treatment avenue for type 2 diabetes patients centring on the activity of the amino acid, GABA.

imaging technique for labelling blood cells

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New optical technique affords unique insight into blood cell development

13 March 2020 | By Mandy Parrett (Drug Target Review)

Scientists in Hong Kong have developed a novel optical technique that facilitates accurate tracking of hemogenic endothelium cells in zebrafish embryos, providing new insights into the mechanisms of blood formation and potential new understanding of diseases such as leukaemia.

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T-cell regulator SLAMF6 may be hindering immunotherapy success

5 March 2020 | By Mandy Parrett (Drug Target Review)

A new study conducted in Israel suggests that T cells’ ability to destroy skin cancer increases in the absence of T-cell regulators called SLAMF6.

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Researchers gain new insight into LRRK2 – a potential cause of Parkinson’s

20 February 2020 | By Mandy Parrett (Drug Target Review)

Scientists in the US have applied a novel technique to finally unravel a particular kinase enzyme that is associated with familial Parkinson’s disease; providing a clearer potential therapeutic target.

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Receptor protein activity could prevent neuropathy for chemotherapy patients

20 February 2020 | By Mandy Parrett (Drug Target Review)

A team of researchers in Singapore has studied the activity of a receptor protein to identify whether it’s a key player in the development of neuropathy for patients undergoing chemotherapy.

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Gene found to protect motor neurons against degeneration

19 February 2020 | By Mandy Parrett (Drug Target Review)

Results of an international collaboration show promise for the future of motor neurone disease treatment efforts, as protective gene is identified.

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Clusterin proteins’ cleanup mechanism is identified

19 February 2020 | By Mandy Parrett (Drug Target Review)

The body’s means of maintaining health are diverse and plentiful, and now researchers in Japan have identified another metaphorical string to its bow: the ability to prevent cell damage using cleanup clusterin proteins that channel damaged proteins for disposal.

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Myc gene linked to alternative splicing changes in several cancers

18 February 2020 | By Mandy Parrett (Drug Target Review)

A collaboration of academic institutions in the United States has identified a gene that is linked to alternative splicing changes that occur in several cancers.

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New variant of the GLA gene to be linked with Fabry cardiomyopathy

17 February 2020 | By Mandy Parrett (Drug Target Review)

A study in Finland has found a strong connection between the A143T variant of the GLA gene and increased risk of Fabry cardiomyopathy, which affects the heart, kidneys and nervous system.

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The fate of cancer is all down to particular proteins

11 February 2020 | By Mandy Parrett (Drug Target Review)

Scientists in Japan have identified an important protein that can impact the course of cancer and its fate in the human body.

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Autophagy: the key to effective MERS-coronavirus treatment?

31 January 2020 | By Mandy Parrett (Drug Target Review)

A promising route for tackling the often-fatal MERS-coronavirus (MERS-CoV) has been identified by researchers in Germany.

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Scientists find leukaemia’s Achilles heel in vitamin B6

15 January 2020 | By Mandy Parrett (Drug Target Review)

A possible new avenue for treatment of Acute Myeloid Leukaemia (AML) has opened up after US scientists pinpoint how the cancer spreads using excessive amounts of vitamin B6.

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Scientists block AHR receptors to treat obesity in mice

15 January 2020 | By Mandy Parrett (Drug Target Review)

A team of scientists in the United States has successfully used a drug, which blocks AHR receptors, to prevent and treat obesity in mice. Their findings have spurred further research into the receptors’ association with diet and the gut microbiome.

Mucin 6 gene indicates late-onset Alzheimer’s

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Mucin 6 gene indicates predisposition to late-onset Alzheimer’s

25 November 2019 | By Mandy Parrett (Drug Target Review)

Scientists have idenified that variation in a gene called Mucin 6 appears to indicate a tendency for acquiring Alzheimer’s disease.

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ORION project launched to research Open Science goals

10 May 2017 | By Mandy Parrett (Drug Target Review)

This week a new collaborative European project is being launched that aims to re-invigorate the way that research into life sciences and biomedicine is organised and funded. The project, named ORION, will be coordinated by The Centre for Genomic Regulation in Barcelona, Spain, who is one of nine partners taking…

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Mandy Parrett (Drug Target Review)