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BMG Labtech GmbH

Product hub: High-throughput screening of cyclic peptide libraries for developing drugs to challenging targets

28 September 2021 | By BMG Labtech GmbH

Professor Christian Heinis explains how peptides could offer the next generation of therapeutics and what is required to screen libraries of cyclic peptides.

whitepaper

Application note: Screening for optimal association and dissociation rates of ligands using a live cell binding assay

28 May 2020 | By BMG Labtech GmbH

Potential drugs not only need to bind to their targets, they also need to remain bound for a specific amount of time in order to work efficiently.

article

Expert view: Promising methods in kinase screening

12 December 2019 | By BMG Labtech GmbH

Kinase-mediated phosphorylation is a control point for nearly all activity within a cell, making kinases important in many diseases.

article

Under the microscope: Improving hit discovery efficiency at Europe´s leading screening centre

17 September 2019 | By BMG Labtech GmbH

Steven van Helden, Chief Technology Officer at Pivot Park Screening Centre (PPSC), relies on efficient microplate readers for effective hit discovery.

article

Webinar highlights: Cell-based and biochemical high-throughput screening in 1536-well plates

5 December 2018 | By BMG Labtech GmbH

The Small Molecule Screening Facility (SMSF) at the University of Wisconsin Madison is a comprehensive high-throughput screening (HTS) centre where researchers have investigated antibiotic-resistant bacterial infections and screening for protein-protein interactions using HTS methods.

article

Under the microscope: CROs and microplate reader requirements

4 December 2018 | By BMG Labtech GmbH

Contract Research Organisations rely on microplate readers for effective hit discovery. Ian Waddell, of Charles River Laboratories, explains what his needs are.

video

Customer testimonial PHERAstar FSX and CLARIOstar

27 November 2018 | By BMG Labtech GmbH

Laura Kilpatrick, Chloe Peach and Carl White from the University of Nottingham talk about cancer research and how they use our microplate readers PHERAstar and CLARIOstar.

whitepaper

Application note: PHERAstar^® measures AlphaScreen assay to develop selective inhibitors for the human YEATS domains

21 November 2018 | By BMG Labtech GmbH

YEATS domains are epigenetic regulators and are recognised as readers of histone post-translational modifications (HPTM) alongside bromodomains, PHD fingers, and others.

video

GPCR binding and signalling studies with the PHERAstar

19 November 2018 | By BMG Labtech GmbH

This video will show how you can do GPCR binding and signalling studies with the PHERAstar.

whitepaper

Application note: Cellular dopamine and intracellular calcium signaling using the next generation HTS microplate reader

16 November 2018 | By BMG Labtech GmbH

This application note highlights the direct optic bottom reading performance of the BMG LABTECH microplate readers in two different cell-based fluorescence intensity assays from Invitrogen.

whitepaper

Application note: Promega’s ADP-Glo™ assay

14 November 2018 | By BMG Labtech GmbH

This application note discusses how the ADP-Glo™ Kinase assay is a universal, homogeneous, high-throughput screening method that measures kinase activity by quantifying the amount of ADP produced during the kinase reaction.

whitepaper

Application note: Increasing throughput with dual emission AlphaLISA-AlphaPlex assay and simultaneous dual emission detection

5 October 2018 | By BMG Labtech GmbH

Multiplexing AlphaLISA type assays will increase throughput while sample expenditure and costs are minimised. The ability of the PHERAstar FS microplate reader to perform simultaneous dual emission detection of this assay will allow users to double the information obtained from each well in the same amount of time as needed…

whitepaper

Application note: Miniaturisation of an HTRF methyltransferase assay that detects histone modifying activity

24 September 2018 | By BMG Labtech GmbH

High throughput screening is mostly done in pharmaceutical companies that test whole libraries of compounds. Reducing the assay volume will reduce operating costs. At the same time it is necessary to prove that the smaller volume will not have a negative impact on assay sensitivity and reliability.

whitepaper

Application note: NanoBRET^TM assay for monitoring of ligand binding to GPCRs in live cells, using the CLARIOstar^® and the PHERAstar^® FS

17 September 2018 | By BMG Labtech GmbH

Due to the crucial role of G protein-coupled receptors (GPCRs) in mediating cellular responses to external stimuli, these receptors have been and will remain a prime focus for medical research and the pharmaceutical industry for many years to come. Their importance is especially highlighted by the statistic that 30-50% of…

article

Cell-based and biochemical high-throughput screening in 1536 well plates

12 September 2018 | By BMG Labtech GmbH

This webinar shines a spotlight on cell-based and biochemical high-throughput screening in 1536 well plates. Supported by BMG LABTECH, the webinar will take place on 30 October at 4:00pm (GMT).

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