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MicroRNA in red blood cells causes vascular damage in type 2 diabetes
Researchers discovered that cardiovascular damage was caused by reduced microRNA-210 levels in patient cells and mice with type 2 diabetes.
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Type-2 diabetes
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Senescent cell treatment could combat age-related diseases
Scientists have developed a novel technique for the targeted clearance of senescent cells to improve treatments for ageing and other conditions.
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Greasy hair proves to be an unexpected possibility for obesity treatment
Researchers have revealed that the immune system of obese mice treated with TSLP released lipids through sebaceous glands.
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Promising new avenue to tackle obesity-related diabetes
New findings from collaborative research in the United States have identified a promising new treatment avenue for type 2 diabetes patients centring on the activity of the amino acid, GABA.
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Drug development in stem cell-derived liver organoid models
To ensure that new drugs are effective and have as little toxicity as possible, they first need to be tested in model systems before entering clinical trials. In this Q&A, Dr Takanori Takebe outlines his research into liver organoids derived from stem cells that can be used to test new…
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Small molecule to potentially treat diabetes discovered in screening study
A small molecule found in a cell-based ultra-high-throughput screening campaign was shown to treat diabetes in cells and mice.
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New synthetic biologic could treat obesity-related diseases
A synthetically made glycopeptide biologic has shown promise as a treatment for obesity-related diseases in mice.
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Five of the latest developments in 3D bioprinting
Drug Target Review brings you five of the most recent developments in three-dimensional (3D) bioprinting.
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β-cell regeneration discovery could pave way for diabetes treatments
A key process in β-cell regeneration has been discovered by researchers who say this could lead to improved treatments for diabetes.
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CNS target could lead to development of drugs for diabetes
Researchers have shown that a GLP-1/GIP dual-agonist targets the GIP receptor in the brain and CNS to reduce body weight and food intake.
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Potential probiotic treatment identified for type 2 diabetes
Researchers have identified microbes that could affect the way a person metabolises glucose and lipids, leading to a potential treatment for type 2 diabetes.
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Engineered protein could be used to treat type 2 diabetes
An engineered form of the SMOC1 protein has shown success as a type 2 diabetes treatment in animal models, say researchers.
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Tuberculosis vaccine shown to protect older mice with type 2 diabetes
A study in older mice with type 2 diabetes revealed a tuberculosis vaccine elicited a strong immune response, making it a promising candidate for the condition.
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SRI-37330 revealed as drug candidate for treatment of diabetes
A study has shown that SRI-37330 is successful at improving the characteristics of diabetes in human pancreatic islets and animal models.
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Novel compound could treat type 2 diabetes without common side effects
Two molecules combined into a new substance to treat type 2 diabetes lowered blood sugar in shrew models without causing nausea, vomiting and weight loss.