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‘Ubiquitin clipping’ proteomics technique could be used as novel treatment
A new technique called ‘ubiquitin clipping’ has been created which could aid proteomics research and the development of new drugs for ubiquitination.
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OX40-expressing follicular helper T cells can control rheumatoid arthritis
New study shows that a subset of follicular helper T cells contributes to the hyposialylation of autoantibodies in rheumatoid arthritis.
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New imaging tools that trace key breast cancer enzymes may help guide therapies
Series of molecules may provide more reliable relief with fewer side effects...
article
Targeting innate immunity to treat disease: potential therapeutic applications
Despite being one of the more ancient aspects of immunity, therapeutic modulation of the innate immune system has rarely been attempted. Innate immunity is intrinsically linked to the generation of inflammation – necessary for signalling to the adaptive immune system but often self-perpetuating and over-exaggerated, leading to deleterious effects, including…
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Neutrophil nanosponges soak up rheumatoid arthritis promoting proteins
The neutrophil nanosponges can absorb and neutralise cytokines which play a role in the development of rheumatoid arthritis...
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Researchers identify new arthritis severity gene
A new gene associated with disease severity in models of rheumatoid arthritis has been identified by...
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A link between Huntington’s disease and rheumatoid arthritis identified
Epigenomic analyses may lead to other unexpected findings and novel therapeutic drug targets for many diseases
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EBV protein can ‘switch on’ risk genes for autoimmune diseases
EBV may trigger some cases of lupus, say NIH-supported researchers...
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Autoimmune disease research community gets boost from AMP RA/SLE study results
Data from the Phase I study of collaborative industry partnership AMP are now available, meaning scientists can benefit from access to important research about Rheumatoid Arthritis and Systemic Lupus Erythematosus.
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Small molecule could make a big difference for arthritis patients
Scientists have discovered a molecule that enhances cartilage regeneration and decreases inflammation.
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Researchers create anti-inflammatory antibodies to treat autoimmune disease
Massachusetts General Hospital (MGH) investigators use enzyme treatment to convert autoantibodies into anti-inflammatory antibodies in animal models of two autoimmune diseases.
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NIH awards $15m to support development of 3-D human tissue models
The NIH has announced 13 two-year awards totalling $15m, to develop 3-D microphysiological system platforms that model human disease...
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Inflammatory biomarkers as a herbal anti-arthritic drug discovery tool
Rheumatoid arthritis (RA) is joint-related, immune-based inflammatory disarray that affects almost 1% of the world’s population. The most evidenced pathogenesis is T-cell activation, which leads to clusters of differentiation (CD) in the T-cells and concurrently increases various inflammatory biomarkers.
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New gene mutations found in white blood cells in rheumatoid arthritis patients
Finnish researchers have found that an accumulation of gene mutations, similar to those typically seen in the development of cancer, also occur in some patients with rheumatoid arthritis.
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Anti-inflammatory drugs could treat symptoms of depression
18 October 2016 | By Niamh Louise Marriott, Digital Content Producer
Anti-inflammatory drugs, like those used to treat rheumatoid arthritis and psoriasis could in future be used to treat some cases of depression...