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NINDS awards Sinopia $3.3m for development of Parkinson’s drug candidate
Sinopia has been awarded a $3.3 million Fast-Track SBIR grant to fund the study for its small molecule candidate for Parkinson’s disease.
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Parkinson's disease (PD)
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Promising pre-clinical data announced for Parkinson’s drug
Stealth BioTherapeutics reported positive data from a pre-clinical study evaluating SBT-272 in a murine model of Parkinson's disease.
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Quantifying method developed to improve neurodegeneration studies
Researchers have created a new method to quantify protein droplets involved in neurodegenerative diseases, enhancing the study of treatments.
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Farnesol shows potential to prevent and treat Parkinson’s disease
Researchers have added to evidence that farnesol prevents and reverses brain damage linked to Parkinson’s disease in mouse models.
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Drug target to halt progression of Parkinson’s disease identified
Scientists have shown that trapped LC3B protein in brain cells enables Parkinson's disease to spread, presenting a drug target.
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New tool designed to add or remove sugar from proteins shows success
Researchers have developed a new tool that can add or remove sugar from proteins, which could be used to treat currently "undruggable" targets.
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Developing bioenergetic nanocatalysts, a novel approach to treat neurodegeneration
Mark Mortenson, CSO of Clene Nanomedicine, discusses the use of proprietary gold nanocrystals as catalysts to prevent the progression of, and act as a treatment for, neurodegenerative disease.
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Structure of protein that triggers neurodegeneration isolated and analysed
Using X-ray crystallography and cryo-electron microscopy, researchers have elucidated the structure of the SARM1 protein, a target for neurodegeneration.
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Could bile acids play a role in Parkinson’s pathogenesis?
A new study suggests bile acids may act as a valuable biomarker for diagnosing and tracking the progression of Parkinson's disease.
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“Organs-on-a-chip” reveal how digestive tract may influence neurological disease
A team has used their new organs-on-a-chip system to replicate the interactions between the brain, liver and colon.
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Precision medicine beyond oncology
The field of oncology has successfully applied precision medicine approaches to diagnosis and treatment. Success has been driven by a growing understanding of the underlying biology of cancer; the emergence of innovative tools and technologies for biomarker identification and detection; and considerable advocacy by patients, physicians and policymakers that has…
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A novel blood-brain barrier model for cerebral malaria research
In this article Maria Bernabeu, Group Leader at EMBL, Barcelona, discusses why it is important to research and develop novel therapeutics for cerebral malaria and how her research group intends to develop a 3D blood-brain barrier model for this purpose.
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Novel technique reveals Parkinson’s changes how neurons sense oxygen
The new approach enables researchers to isolate brain cells associated with Parkinson's disease and study their gene expression patterns.
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Stem cell therapy repairs Parkinson’s degeneration in mice
Researchers demonstrate that transplanting dopaminergic neurons grown from stem cells into the brains of mice improved motor skills.
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Astrocytes likely contribute to Parkinson’s disease progression
A new study shows astrocytes derived from monogenic Parkinson’s patients have metabolic alterations that mean they could be contributing to disease progression.
