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Lupus

Determining the structure of nanobodies using nuclear magnetic resonance spectroscopy

23 September 2021 | By Professor Gennaro Esposito (NYU Abu Dhabi)

Scientists at the New York University (NYU) Abu Dhabi have used nuclear magnetic resonance (NMR) techniques to determine the structure of a specific nanobody, Nb23. Drug Target Review’s Victoria Rees spoke with lead researcher Professor Gennaro Esposito to find out how their findings could lead to a better understanding of…

news

Inhibiting IRE1α pathway could be novel therapeutic strategy for lupus

29 March 2021 | By Victoria Rees (Drug Target Review)

A study has revealed that blocking a molecule called IRE1α could prevent the release of neutrophil extracellular traps in lupus pathogenesis.

news

Bioactive compound in ginger could be used in treatment of lupus

7 January 2021 | By Victoria Rees (Drug Target Review)

According to new research, the bioactive compound of ginger root, 6-gingerol, prevented disease progression of lupus in mice.

news

Potential target to control T follicular helper cells identified

23 June 2020 | By Victoria Rees (Drug Target Review)

A new study shows how the Bcl6 protein can regulate T follicular helper cells, presenting a target for autoimmune and infectious diseases.

diabetic person using pre-filled syringe to inject their stomach with insulin

news

Genetic deletion permanently prevented type 1 diabetes development in mice

30 March 2020 | By Hannah Balfour (Drug Target Review)

Researchers observed that deleting the IRE1-alpha gene caused beta cells to de-differentiate and then re-differentiate in mice, preventing immune system auto-activation.

Molecule of blood found to be effective against autoimmune kidney disease

news

Molecule of blood found to be effective against lupus

4 February 2020 | By Rachael Harper (Drug Target Review)

Scientists have found that a molecule present in our blood, called C4BP (β-), could be used in a therapeutic capacity for lupus as well as potentially other autoimmune disorders.

article

DTR’s news round-up 2019: the stories that defined the year

18 December 2019 | By Drug Target Review

Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.

news

New insights found into lupus may help combat the disease

17 December 2019 | By Rachael Harper (Drug Target Review)

A new study may lead to new treatments for lupus as it has found that, when impaired, a key regulator of the immune system can cause damaging immune system attacks on skin and organs, which are hallmarks of the disease.

news

Better HIV, lupus and hep C treatments possible with malaria discovery

20 November 2019 | By Rachael Harper (Drug Target Review)

A new discovery on how the immune system responds to malaria infection could lead to better treatments for hepatitis C, HIV and lupus.

news

Role of gut microbiota studied in pregnant women with lupus

16 September 2019 | By Rachael Harper (Drug Target Review)

New research findings suggest that gut microbiota may regulate lupus flares in pregnant women, presenting a therapeutic target.

news

Study identifies novel lupus drug target

3 June 2019 | By Victoria Rees (Drug Target Review)

Structure of internal regulator molecule identified, presenting lupus drug potential.

news

Captopril may prevent memory loss in lupus patients

5 September 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have discovered that the activation of brain cells contributes to the memory loss and other cognitive impairments suffered by many patients with systemic lupus erythematosus...

news

Researchers use blood serum markers to develop lupus risk index

1 June 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have developed an index that identifies the risk for lupus based on the presence and amount of IgG and IgM antibodies and levels of C1q...

A novel pathway to regulate B cell activity and prevent autoimmunity

news

A novel pathway to regulate B cell activity and prevent autoimmunity

10 April 2018 | By Drug Target Review

Researchers at the Medical University of South Carolina (MUSC) have identified a novel checkpoint of peripheral tolerance, specifically in B cells.

news

DNA gets away: Scientists catch the rogue molecule that can trigger autoimmunity

22 February 2018 | By Drug Target Review

A research team has discovered the process - and filmed the actual moment - that can change the body’s response to a dying cell.

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