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Lung cancer

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Club cell factors may reverse immune suppression in tumours

21 September 2021 | By Anna Begley (Drug Target Review)

New research has revealed that club cells secret anti-immunosuppressive factors in tumours, potentially revolutionising cancer therapies.

news

Genomic study uncovers causes of lung cancer in non-smokers

8 September 2021 | By Anna Begley (Drug Target Review)

An NIH study used whole genome sequencing to describe three molecular subtypes of lung cancer in non-smokers, possibly improving treatments.

news

Computational method developed to map chromosome folding in 3D

27 May 2021 | By Victoria Rees (Drug Target Review)

Researchers created their new method to analyse chromosomes in 3D, revealing how misconfigurations play a role in cancer.

news

Single-cell map of lung cancer sheds light on tumour development

11 May 2021 | By Victoria Rees (Drug Target Review)

A spatial atlas of early-stage lung cancer has been compiled at single-cell resolution, revealing new therapeutic targets.

news

Compound that targets BRAT1 protein could be used to kill cancer cells

22 April 2021 | By Victoria Rees (Drug Target Review)

Having synthesised the curcusone D compound, researchers demonstrated its promise as the first BRAT1 inhibitor, making it a potential cancer therapy.

article

Could metabo-oncology be the treatment modality of the future?

8 February 2021 | By Victoria Rees (Drug Target Review)

Jim Shanahan from SynDevRx explains why metabo-oncology treatment modalities could be the answer to a rise in metabolic disorders and cancers.

news

Tissue damage and genetic mutations interact to drive pancreatic cancer, finds study

4 February 2021 | By Hannah Balfour (Drug Target Review)

New research shows tissue damage to cells carrying KRAS mutations induces epigenetic changes that promote pancreatic cancer.

article

The Editors’ views: Drug Target Review’s 2020 round-up

14 December 2020 | By Hannah Balfour (Drug Target Review), Victoria Rees (Drug Target Review)

The Junior Editors of Drug Target Review, Victoria Rees and Hannah Balfour, discuss some of the most noteworthy news and announcements from this year.

article

A rational approach to discover and precision-engineer new biologic drugs

2 December 2020 | By Jerome Boyd-Kirkup (Hummingbird Bioscience)

When it comes to developing antibody drugs, Dr Jerome Boyd-Kirkup and his team are not sticking to the classical playbook. Here, he explains how they use systems biology and immuno-engineering to remove the element of luck from biologic drug discovery and development.

news

Cancer-killing virus could improve precision medicine

2 December 2020 | By Victoria Rees (Drug Target Review)

A new cancer-killing virus called CF33 has shown success in pre-clinical trials, helping the immune system to eradicate tumours.

cancerous cell with crosshares over it - idea of targetted cancer therapy

news

LMTK3 inhibitors could be an effective breast cancer therapy, say scientists

16 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers demonstrate that inhibiting the LMTK3 kinase is an effective anticancer strategy in murine models of breast cancer.

news

Novel vaccine protects mice from lung, bowel and pancreatic cancer

23 October 2020 | By Victoria Rees (Drug Target Review)

By targeting the mutated KRAS gene, researchers have developed an experimental vaccine that protected mice against a range of cancers.

RNA strand on an abstract orange swirling background

news

Long non-coding RNAs could be future targets for cancer drugs

16 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers have implicated long non-coding RNAs in tumour progression and suggest they may be potential drug targets for cancers with p53 mutations.

Futuristic image - DNA stand with scissors about to cut it - idea of CRISPR gene editing

news

CRISPR used to eliminate cancers caused by fusion genes

9 October 2020 | By Hannah Balfour (Drug Target Review)

Using CRISPR to cut out fusion genes, scientists were able to specifically induce cancer cell death in murine models of sarcoma and leukaemia.

news

Circular RNA revealed as drug target for lung squamous cell cancer

28 September 2020 | By Victoria Rees (Drug Target Review)

After finding that the circular RNA called CDR1as plays a role in driving metastasis, researchers have identified it as a potential target for lung squamous cancer.

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Lung cancer