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Study finds astrocytes critical in progression of Huntington’s disease
The new research shows that astrocytes contribute to Huntington’s disease symptoms, but suppressing a mutation stops the disease from progressing.
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Huntington's disease
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New technology developed to screen for Huntington’s treatments
Researchers have created a new technology which enabled them to discover more about the causes of Huntington’s disease and which can be used to test drugs.
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The elegant parallel of using CRISPR to understand disease mechanisms
CRISPR is the buzzword of the moment in the drug discovery industry – mainly due to its potential to correct disease-causing mutations. However, those using the technology need to be mindful that it is used responsibly, and possible risks are considered before use. Mark Behlke discusses the potential of CRISPR…
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Revealed autophagy mechanism is potential dementia target
A study has discovered the regulating process behind cell autophagy which could aid in the development of neurodegenerative disease treatments.
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Novel nanoparticles improve CRISPR gene editing
A study has used new synthetic lipids to deliver CRISPR gene editing tools into cells with up to 90 percent efficiency.
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Class of neurological disorders share 3D genome folding pattern
Researchers have found another common thread linking nearly all of the TNR expansion diseases...
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Short protein fibres predict the onset and course of Huntington’s disease
A research team has reported that short protein fibres precede the formation of larger deposits that accumulate in the brains of those affected by the incurable Huntington's disease...
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Powerful molecules provide new findings about Huntington’s disease
Researchers have discovered a direct link between the protein aggregation in nerve cells that is typical for neurodegenerative diseases, and the regulation of gene expression in Huntington's disease...
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CRISPR technique skips over portions of genes that can cause disease
Researchers have adapted CRISPR to cause the cell's internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building...
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UBR5 protein may reduce neurodegeneration in Huntington’s disease
Scientists have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington's disease...
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New insight into Huntington’s disease may open door to drug development
Researchers have developed a new theory on Huntington's disease which is being welcomed for showing promise to open new avenues of drug development for the condition...
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Molecular alterations provide insight into Huntington’s disease
Scientists have applied their high-throughput, multi-pronged approach to Huntington's disease, and uncovered the functional significance of various molecular changes...
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A link between Huntington’s disease and rheumatoid arthritis identified
Epigenomic analyses may lead to other unexpected findings and novel therapeutic drug targets for many diseases
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Lab-on-a-chip device mimics eye damage due to intense light
Researchers create eye neuron network model to study retinal diseases, possible treatment options...
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CRISPR used to edit DNA outside of the cell
Scientists have developed a breakthrough CRISPR gene-editing tool, that could allow researchers to quickly and precisely engineer multiple changes to the genetic code...
