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Modified CRISPR gene editing tool could improve therapies
New cell experiments show more effective genetic 'cuts' that could one day become the foundation of more effective gene therapies.
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New HIV vaccine candidate design developed by researchers
A study has demonstrated a novel vaccine design in mice which could be used to immunise patients against HIV.
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Hitting the target – utilising recombinant antibodies for viral research
Having worked in antibody research for over 20 years, Gary McLean has seen how the industry has progressed and understands the potential that antibodies have in the future of medicine. Nikki Withers hears how the focus has shifted from discovery to genetic sequence manipulation and how this can be applied…
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HIV infant model opens new avenues for research
An animal model to test HIV infection in infants could lead to biomarkers that predict viral rebound after ART interruption.
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‘Reverse vaccinology’ used to create novel HIV treatment
Researchers have developed a new HIV vaccine which has shown success in monkeys in pre-clinical trial studies.
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New version of HIV vaccine could soon be ready for clinical trials
A promising vaccine that clears an HIV-like virus from monkeys is closer to clinical trial human testing.
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Potential cure for HIV revealed through combined therapies
A new study has used combined therapies to eliminate HIV from mice models, providing potential future cures.
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‘CRISPR babies’ may have shorter life expectancy
A study of almost half a million people links a mutation that protects against HIV infection to an earlier death.
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Custom-made proteins create antibodies to fight HIV
Computational modelling has been used to design proteins that mimic the conserved protein surface of different strains of HIV for use in vaccines...
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Fighting HIV using anti-cancer immunotherapy
Researchers have used immunotherapy treatments, ordinarily used to treat cancer, to reveal the virus in the cells of people living with HIV...
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Neutralising antibodies could lead to HIV vaccine
Developing an HIV vaccine focuses on discovering the factors responsible for the production of antibodies that neutralise almost all known virus strains...
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IgG3 antibody can block B cells from fighting pathogens during HIV infection
Scientists have shown that in certain people living with HIV, a type of antibody called immunoglobulin G3 stops the immune system's B cells from doing their normal job of fighting pathogens...
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Computer simulations predict the spread of HIV
Genetic signatures trace the origin of infection and its potential path through populations, allowing state health departments to track the disease...
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HIV vaccine elicits antibodies in animals that neutralise dozens of HIV strains
NIH study results represent a major advance for structure-based HIV vaccine design...
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CRISPR used to destroy the regulatory genes of HIV
By destroying the regulatory genes of the AIDS virus HIV-1 using the genome editing system CRISPR/Cas9, researchers have succeeded in blocking the production of HIV-1 by infected cells...
