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Targeting PEG2 reverses age-related cognitive decline in mice
The discovery of an inflammatory pathway promoting brain ageing and cognitive decline could lead to new treatments for age-related conditions.
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Structure of lipin enzyme responsible for triglycerides revealed for first time
Researchers have obtained the crystal structure of the lipin enzyme, the regulator of triglyceride production, which they say could inform research into heart disease, obesity and diabetes.
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CRISPR: kick-starting the revolution in drug discovery
Gene editing using the CRISPR system has been established as the most powerful tool in the search for new drugs and is now being exploited for therapeutic purposes. Here, Pushpanathan Muthuirulan discusses the promises and wider opportunities of using CRISPR technology to open up the possibility of large-scale screening of…
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CAR T-cell therapy could be harnessed to treat heart disease
New study finds immunotherapy reduces cardiac fibrosis and restores heart function in mice after cardiac injury.
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RNA-seq of 20,000 cardiac cells reveals heart disease insights
RNA analysis of 20,000 cardiac cells from heart tissue in both ordinary and deceased mice showed an insight to the development of heart disease...
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Brain changes responsible for the appetite effects of cannabis identified
New research on how cannabis use alters eating behaviour could lead to treatments for appetite loss in chronic illness...
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3D map of CVD genetic interactions could aid future treatments
A 3D map of genetic interactions in CVD could aid researchers investigating future treatments for heat attacks, heart failure and heart rhythm disorders.
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CRISPR technology may improve accuracy of predicting heart disease risk
Scientists may now be able to predict whether carrying a specific genetic variant increases a person's risk for disease using gene editing and stem cell technologies...
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New target for treating heart failure identified by Penn Medicine researchers
Reversing modifications in diseased heart muscle cell struts called microtubules (MT) can lessen the stiffness and improve the beating strength of these cells isolated from transplant patients with heart failure.
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Controlling immune cell migration as therapy for heart disease
Researchers in the United States find that the location of the body’s immune cells correlates precisely with their function related to heart disease.
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Early stimulation improves performance of bioengineered human heart cells
Researchers are now able to use induced pluripotent stem cells to form a model of human adult-like cardiac muscle...
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Scientists discover promising off-switch for inflammation
Scientists have discovered that itaconate - a molecule derived from glucose - acts as a powerful off-switch for macrophages...
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A1C proteins associated with diabetic complications and heart disease
Protein pathways that are closely linked to changes in both triglyceride and haemoglobin A1c levels in diabetic patients have been identified...
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Researchers create enhanced nanoscaffold for regenerative heart medicine
Biophysicists in Russia have gained greater understanding about the structure of nanofibrous scaffolds – termed nanoscaffolds – in a study that is researching heart tissue regeneration.
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STEEL gene senses inadequate blood flow in microscopic blood vessels
A new study has found that a newly discovered gene helps grow blood vessels when it senses inadequate blood flow to tissues...
