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Ebola

The development of biomaterial-based vaccine platforms against viruses

31 March 2021 | By Dr Kaushik Chatterjee (Indian Institute of Science), Dr Sonal Asthana (Indian Institute of Science), Dr Sushma Kumari (Indian Institute of Science)

Recent years have seen an increase in the development of biomaterial and nanoparticle-based vaccine formulations. Sushma Kumari, Sonal Asthana and Kaushik Chatterjee from the Department of Materials Engineering at the Indian Institute of Science discuss why these materials have such high potential in the fight against infectious diseases.

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Three common antiviral drugs effective against SARS-CoV-2 in vitro

25 March 2021 | By Victoria Rees (Drug Target Review)

A team has shown that tilorone, quinacrine and pyronaridine are effective at inhibiting the replication of SARS-CoV-2 in vitro.

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New small molecules can prevent filovirus infection in cells

9 February 2021 | By Victoria Rees (Drug Target Review)

Through a series of experiments, researchers have identified small drug molecules that can inhibit filoviruses such as Ebola and Marburg.

mouse in laboratory with paws on scientist's gloved hand

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Inhaled vaccine induces strong immune response in animal models

11 December 2020 | By Hannah Balfour (Drug Target Review)

Scientists report their phage-based inhaled vaccine delivery system elicited a robust antibody response in both mice and non-human primates.

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Neuropilin-1: a key receptor in SARS-CoV-2 infection

27 November 2020 | By Nikki Withers (Drug Target Review)

Results of a recent study by researchers at the University of Bristol indicate neuropilin-1 is an important host factor for SARS-CoV-2 infection. The team suggests that blocking neuropilin-1 may be a valuable therapeutic intervention in the treatment of COVID-19. Nikki Withers spoke to one of the study’s lead investigators, Dr…

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Promising COVID-19 drug candidate identified by virtual screening

25 June 2020 | By Victoria Rees (Drug Target Review)

After virtually screening 640 existing drug compounds, researchers have revealed that PC786 potently targets several SARS-CoV-2 receptors, making it a candidate to fight COVID-19.

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CD47 blockade could work as immunotherapy across multiple diseases

24 June 2020 | By Victoria Rees (Drug Target Review)

Researchers have demonstrated that blocking CD47-mediated signalling in mice can enhance the speed of pathogen clearance, presenting a new potential form of immunotherapy.

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Universal Ebola vaccine shows promise in pre-clinical trials

17 April 2020 | By Victoria Rees (Drug Target Review)

An Ebola vaccine that has been tested in animals could potentially be used to neutralise four species of the virus, say the researchers.

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The race to find a coronavirus treatment: are antibodies the answer?

26 March 2020 | By Nikki Withers (Drug Target Review)

At the beginning of March, US President Donald Trump pressed the pharmaceutical industry to “accelerate the development” of vaccines and therapies to contain the outbreak of the coronavirus pandemic. This article explores what is currently known about COVID-19 and potential treatments that are in the pipeline.

Antiviral compound could be used to fight influenza

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Antiviral compound could be used to fight influenza

22 January 2020 | By Rachael Harper (Drug Target Review)

A study in mice has found that a compound modelled on a protein found in bananas safely protects against multiple strains of the influenza virus.

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Mutant form of Ebola could be used in vaccine development

17 September 2019 | By Victoria Rees (Drug Target Review)

A study has shown that a mutated form of the Ebola virus protects macaque models against the disease, demonstrating an opportunity for a drug target.

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Drug targets for Dengue, Zika and Ebola viruses

14 December 2018 | By Drug Target Review

US researchers have identified possible drug targets for Dengue, Zika and Ebola viruses…

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CLR01 protein found in semen increases the spread of Ebola virus infection

26 June 2018 | By Drug Target Review

Penn study suggests that targeting amyloid fibrils could prevent sexual transmission...

Research enables screening millions of human antibodies for new drug discovery

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Research enables screening millions of human antibodies for new drug discovery

18 January 2018 | By Drug Target Review

Researchers have outlined a pioneering method of screening a person’s diverse set of antibodies for rapid therapeutic discovery.

TSRI scientists discover workings of first promising Marburg virus treatment

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TSRI scientists discover workings of first promising Marburg virus treatment

11 January 2018 | By Drug Target Review

Scientists at The Scripps Research Institute (TSRI) have discovered the workings of the first promising treatment for Marburg virus, a pathogen with the same pandemic potential as Ebola virus.

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Ebola