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Covid-19

orange blobby cytokine binding to a recetor on a blue macrophage

news

Novel targeting peptide shows promise against COVID-19 cytokine storm

3 July 2020 | By Hannah Balfour (Drug Target Review)

Experimental peptide combination TAT CARMIL1 reduced collagen degradation as a result of cytokine storm in ex vivo study.

article

The coronavirus: seasonality and host-specific action of a “sexy” killer

2 July 2020 | By Dr Ulrich Kutschera (University of Kassel)

Dr Ulrich Kutschera outlines why more studies are necessary before the spread and deadliness of the novel coronavirus is fully understood.

news

Study reveals how SARS-CoV-2 rewires human proteins for replication

1 July 2020 | By Victoria Rees (Drug Target Review)

A team of researchers has analysed how SARS-CoV-2 hijacks the proteins in its host cells to aid replication and infect nearby cells.

news

Therapies targeting AhRs and IDO1 could combat COVID-19, paper says

30 June 2020 | By Victoria Rees (Drug Target Review)

Researchers have hypothesised that treatments targeting the downregulation of AhRs and IDO1 genes could reduce severity of COVID-19 infection.

news

Six molecular targets for COVID-19 identified by researchers

30 June 2020 | By Victoria Rees (Drug Target Review)

A study of blood samples from COVID-19 patients has allowed a team to reveal six molecular targets that could be used to develop treatments for the virus.

news

X-rays reveal structure of SARS-CoV-2 protease at room temperature

29 June 2020 | By Victoria Rees (Drug Target Review)

Researchers grew large crystals and used an X-ray machine with a less intense beam to elucidate the structure of the SARS-CoV-2 main protease at room temperature.

news

Study identifies 68 genes associated with risk of severe COVID-19

26 June 2020 | By Victoria Rees (Drug Target Review)

A study has revealed 68 protein-coding genes associated with risk of severe COVID-19, nine of which are targeted by drugs currently in clinical trials.

news

Promising COVID-19 drug candidate identified by virtual screening

25 June 2020 | By Victoria Rees (Drug Target Review)

After virtually screening 640 existing drug compounds, researchers have revealed that PC786 potently targets several SARS-CoV-2 receptors, making it a candidate to fight COVID-19.

news

Over 718 drugs in pipeline as potential COVID-19 treatments, says report

25 June 2020 | By Victoria Rees (Drug Target Review)

New research has found that of the 718 pipeline drugs associated with COVID-19, 70 percent are currently in the discovery or pre-clinical stages.

news

PL8177 shows success as COVID-19 therapy in pre-clinical trials

24 June 2020 | By Victoria Rees (Drug Target Review)

The drug candidate PL8177 reduced inflammation, protected lung tissue and reduced lung fibrosis in pre-clinical models with symptoms of COVID-19.

news

CD47 blockade could work as immunotherapy across multiple diseases

24 June 2020 | By Victoria Rees (Drug Target Review)

Researchers have demonstrated that blocking CD47-mediated signalling in mice can enhance the speed of pathogen clearance, presenting a new potential form of immunotherapy.

news

Open source all-atom model of entire COVID-19 S protein released

23 June 2020 | By Victoria Rees (Drug Target Review)

Researchers have developed a video and model-building programme for other scientists to build full-length COVID-19 S protein models.

news

N terminal domain of S protein revealed as antibody target for COVID-19

23 June 2020 | By Victoria Rees (Drug Target Review)

An antibody with high neutralising potency against SARS-CoV-2 that binds to the N terminal domain of the Spike protein has been identified by a team researching COVID-19 therapeutics.

news

Method to convert any mouse into COVID-19 model made available to researchers

22 June 2020 | By Victoria Rees (Drug Target Review)

Researchers who reported that delivering the human ACE2 protein into mouse airway cells creates COVID-19 models have released their findings to allow other scientists to make their own models.

news

Vaccine adjuvant provides long-lasting protection against HIV in monkeys

22 June 2020 | By Victoria Rees (Drug Target Review)

A vaccine adjuvant named 3M-052 was able to provide rhesus monkeys with protection against HIV for over a year, a new study reports.

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