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Coronavirus

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EIDD-2801 shows efficacy against COVID-19 in human cells and mice

7 April 2020 | By Hannah Balfour (Drug Target Review)

Collaborators have shown that the broad spectrum oral antiviral EIDD-2801 could be a potential prophylactic or therapeutic for COVID-19 and other coronaviruses.

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Researchers reveal how SARS antibody binds to COVID-19 coronavirus

7 April 2020 | By Victoria Rees (Drug Target Review)

The interaction between a SARS antibody called CR3022 and the COVID-19 coronavirus has been mapped by researchers, revealing a viral vulnerability.

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Celltrion to select lead antibody candidates to fight COVID-19

6 April 2020 | By Victoria Rees (Drug Target Review)

Following the screening of antibodies, Celltrion will now identify the most potent out of 300 hits that work against the COVID-19 coronavirus best.

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Collaboration to develop inhaled mRNA-based antibody therapy for COVID-19

6 April 2020 | By Hannah Balfour (Drug Target Review)

Two companies, Neurimmune and Ethris, will leverage their technologies to research, develop and produce an inhaled therapy for COVID-19.

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Ivermectin shows activity against COVID-19 in cell cultures

6 April 2020 | By Hannah Balfour (Drug Target Review)

A study has demonstrated that the anti-parasitic drug ivermectin may be effective against SARS-CoV-2, the virus which causes COVID-19.

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Novel COVID-19 vaccine shows efficacy in mice

3 April 2020 | By Victoria Rees (Drug Target Review)

Researchers have developed a vaccine against the COVID-19 coronavirus which induced the rapid production of antibodies in mice.

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Decoy ACE2 receptors could be promising COVID-19 infection-preventing drug

3 April 2020 | By Hannah Balfour (Drug Target Review)

Recombinant angiotensin converting enzymes (ACE2) reduced infection and viral growth in cell cultures and organoids by acting as a decoy for SARS-CoV-2.

man using a nasal spray being observed by a researcher/doctor in a lab coat, making notes on a clipboard

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Biotech and academia collaborate on intranasal COVID-19 vaccine development

2 April 2020 | By Hannah Balfour (Drug Target Review)

The University of Alabama at Birmingham (UAB) will run the pre-clinical trials of Altimmune’s intranasal COVID-19 vaccine candidate, AdCOVID.

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AI technology to screen existing drugs for use against COVID-19

2 April 2020 | By Victoria Rees (Drug Target Review)

A collaboration aims to utilise a compound library of 15,000 clinically-ready molecules and screen then against three COVID-19 targets.

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COVID-19 update: funding for treatments and vaccines

1 April 2020 | By Victoria Rees (Drug Target Review)

Drug Target Review rounds up the latest announcements regarding funding for research into COVID-19 treatments and vaccines.

researcher in lab coat touching drug design icon

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Free access to AI Clinical Research Navigator tool for COVID-19 researchers

1 April 2020 | By Hannah Balfour (Drug Target Review)

In light of the COVID-19 pandemic, the creators of the Clinical Research Navigator (CRN) tool have offered free access to their system for biomedical researchers.

face mask, white tablets and syringe of medication

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Nafamostat inhibits SARS-CoV-2 infection, preventing COVID-19 transmission

31 March 2020 | By Hannah Balfour (Drug Target Review)

Researchers have demonstrated that Nafamostat mesylate (Fusan) can inhibit SARS-CoV-2 Spike protein-initiated membrane fusion at concentrations likely achievable and safe in patients.

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Johnson & Johnson identifies lead COVID-19 vaccine candidate

31 March 2020 | By Victoria Rees (Drug Target Review)

A lead COVID-19 vaccine candidate has been selected by Johnson & Johnson, after demonstrating promise in pre-clinical testing.

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Novel antiviral compound proposed as COVID-19 therapeutic

30 March 2020 | By Victoria Rees (Drug Target Review)

A molecule called BOLD-100, developed to fight cancer, has been suggested as a therapeutic to combat the COVID-19 coronavirus due to its antiviral properties.

bags of yellow-coloured blood plasma labelled for use as therapeutics

news

FDA and BARDA to collaborate with Grifols on COVID-19 therapeutics

30 March 2020 | By Hannah Balfour (Drug Target Review)

Grifols will leverage their resources to develop and test convalescent plasma-derived COVID-19 therapeutics in partnership with the FDA and BARDA.

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