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Cancer

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Blocking T_reg pathway sensitises mice to immunotherapy

25 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that inhibiting Treg activation in tumours can provide effective immune responses without autoimmune toxicity.

news

High-throughput screening assay for macrocyclic peptides developed

23 February 2021 | By Victoria Rees (Drug Target Review)

A high-throughput screening assay for macrocyclic peptides with affinity to ubiquitin has been created by researchers.

news

Researchers find MAPK4 enzyme presents target for prostate cancer

22 February 2021 | By Victoria Rees (Drug Target Review)

Research has shown that MAPK4 activates two molecules in cellular signalling pathways involved in prostate cancer growth.

news

LEAP proton therapy could target cancer cells that resist treatment

18 February 2021 | By Victoria Rees (Drug Target Review)

A proton therapy that targets cancer cells which are resistant to treatment has shown success, sparing surrounding healthy cells.

news

STING activation reduces graft-versus-host disease in mouse model

12 February 2021 | By Victoria Rees (Drug Target Review)

A team has shown that STING activation is a new molecular target in the fight against graft-versus-host disease (GVHD).

news

Platform reveals insights into cancer genomics and personalised medicine

9 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a personalised medicine platform that could advance genomic medicine research for cancer.

news

Study provides insight into muscle wasting in cancer patients

4 February 2021 | By Victoria Rees (Drug Target Review)

Using a mouse model, researchers found that cancer progression led to fewer skeletal muscle ribosomes, likely explaining muscle wasting.

news

Targeting the HCF-1 protein causes cancerous cells to self-destruct

1 February 2021 | By Hannah Balfour (Drug Target Review)

Disrupting the interaction between the MYC oncogene and its co-factor, host cell factor (HCF)–1, was sufficient to cause Burkitt’s lymphoma cells to self-destruct in vivo.

news

Researchers develop novel way to identify new cancer drugs

26 January 2021 | By Victoria Rees (Drug Target Review)

A team has developed a new way to discover peptide therapeutics that inhibit HDAC enzymes and are effective against cancer.

old woman with back of head disintegrating - idea of age related cognitive decline

news

Targeting PEG₂ reverses age-related cognitive decline in mice

21 January 2021 | By Hannah Balfour (Drug Target Review)

The discovery of an inflammatory pathway promoting brain ageing and cognitive decline could lead to new treatments for age-related conditions.

news

New probes shine a light on the role of four-stranded DNA in human cells

14 January 2021 | By Hannah Balfour (Drug Target Review)

A better understanding of the role of four-stranded DNA (G-quadruplex) could enhance cancer therapeutics, said the developers of the probes.

T cells in red attacking a white tumour/cancerous cell - idea of immunotherapies

news

Study shows how to improve cancer treatment with anti-OX40 antibodies

11 January 2021 | By Hannah Balfour (Drug Target Review)

New insights into the mechanisms of anti-OX40 antibodies could enable their therapeutic activity to be manipulated to treat different tumours.

T cell overlaid on a test tube - idea of drug discovery for conditions with an immune component, eg, cancer or autoimmune diseases

article

A single approach to creating effective cancer and autoimmune disease therapeutics

8 January 2021 | By Dr H Michael Shepard (Enosi Life Sciences)

Dr H. Michael Shepard, CEO and CSO of Enosi Life Sciences, discusses the similarities between cancer and autoimmune diseases, highlighting how this knowledge could be used to enhance treatments.

news

Immunotherapy with radiotherapy could improve outcomes of cancers in liver

6 January 2021 | By Victoria Rees (Drug Target Review)

Researchers have discovered that in mice with cancers in the liver, immunotherapy and radiotherapy prevented T-cell death.

news

NIK could be key to enhancing the effects of immunotherapy

6 January 2021 | By Hannah Balfour (Drug Target Review)

Immunology study shows that NF-kappa B-inducing kinase (NIK) is critical to T cell metabolism and the antitumour immune response.

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Cancer