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Cancer

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news

UTX gene mutation “robs” individuals of natural cancer protection

10 November 2021 | By Anna Begley (Drug Target Review)

The UTX gene mutation was found to lead to an increased cancer risk, presenting a potential drug target for preventative therapies.

news

NMR method could uncover details of cancer and neurodegeneration development

1 November 2021 | By Anna Begley (Drug Target Review)

Scientists have used nuclear magnetic resonance (NMR) spectroscopy to investigate the protein p53, which they say could advance cancer studies.

news

Novel label-free exosome profiling method shows success at detecting cancer

29 October 2021 | By Victoria Rees (Drug Target Review)

A new label-free technique has been developed for molecularly specific exosome biosensing in diagnostics and biomarker detection.

video

Engineering better CAR T cells with Professor Ann Ager, Cardiff University

27 October 2021 | By Drug Target Review

Watch this exclusive interview with Professor Ann Ager, Cardiff University, to discover how CAR T cells could be targeted against solid tumours.

news

$7.5 million to fund senescent cell research for age-related disease

22 October 2021 | By Anna Begley (Drug Target Review)

Washington University will receive $7.5 million from the NIH to study senescent cells for treatments against age-related diseases.

news

MIT study reveals how lipid imbalance affects cancer growth in mice

21 October 2021 | By Anna Begley (Drug Target Review)

In a new study, a calorie-restricted diet significantly reduced tumour growth in mouse models, suggesting new possibilities for cancer therapies.

news

Medicenna’s MDNA11 a promising alternative to checkpoint inhibitors

19 October 2021 | By Anna Begley (Drug Target Review)

Medicenna's IL-2 super-agonist, MDNA11, successfully induced antitumour cells in animal models, a pre-clinical study has revealed.

article

Improving drug discovery with advanced targeted proteomic monitoring workflows

30 September 2021 | By Dr Lauren Stopfer (BioNTech), Professor Forest White (MIT)

In this article, Professor Forest White, Department of Biological Engineering at MIT, and Dr Lauren Stopfer, Scientist at BioNTech, present a novel assay approach for the rapid, reproducible and accurate identification of potential therapeutic targets using mass spectrometry.

article

High-throughput 3D cell migration assays in organ-on-a-chip technologies

30 September 2021 | By Désirée Goubert (MIMETAS), Dr Lenie van den Broek (MIMETAS), Luuk de Haan (MIMETAS), Thomas Olivier (MIMETAS)

Organ-on-a-chip models can provide an alternative to cell cultures, animal models and traditional assays. In this article, Dr Désirée Goubert, Thomas Olivier, Luuk de Haan and Dr Lenie van den Broek explore the advantages of organ-on-a-chip technologies and how they can enable the in vitro study of three-dimensional (3D) cell migration in…

White pills on black surface with COVID-19 structure drawn on

news

Scientists uncover mechanisms of potential COVID-19 drug targets

28 September 2021 | By Anna Begley (Drug Target Review)

Researchers have used CRISPR and cryogenic electron microscopy to unravel the workings of two receptors involved in diseases such as cancer and COVID-19.

news

“Ultrasensitive” HPV detection paves way for precision treatment

28 September 2021 | By Anna Begley (Drug Target Review)

A new study sequenced tumour DNA for the “ultrasensitive” detection of HPV, further honing precision treatment of the illness.

news

New AI method could aid in development of T cell-based cancer therapies

24 September 2021 | By Anna Begley (Drug Target Review)

An artificial intelligence technique can identify which neoantigens are recognised by the immune system, possibly improving cancer prognosis and treatment.

news

Club cell factors may reverse immune suppression in tumours

21 September 2021 | By Anna Begley (Drug Target Review)

New research has revealed that club cells secret anti-immunosuppressive factors in tumours, potentially revolutionising cancer therapies.

news

Novel tool can estimate number of T cells in cancer tumours

10 September 2021 | By Anna Begley (Drug Target Review)

Researchers have developed a new method that can rapidly count the number of T cells in a tumour, helping to predict patient response to therapies.

news

STING-activating drugs could customise cancer treatments

9 September 2021 | By Anna Begley (Drug Target Review)

An imaging technique identified emerging drugs that activate the STING protein to alter metabolic pathway activity in cancer cells.

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Cancer