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Brain cancer

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Therapeutic target for aggressive cancers discovered through CRISPR

5 August 2021 | By Anna Begley (Drug Target Review)

The RNA-modifying protein METTL1 could be targeted to treat some types of aggressive cancers, including brain, blood and kidney.

news

Compound that targets BRAT1 protein could be used to kill cancer cells

22 April 2021 | By Victoria Rees (Drug Target Review)

Having synthesised the curcusone D compound, researchers demonstrated its promise as the first BRAT1 inhibitor, making it a potential cancer therapy.

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Role of gene in metastasis of brain cancer revealed

9 December 2020 | By Victoria Rees (Drug Target Review)

Researchers have shown how increased YTHDF3 expression correlates with brain cancer metastases, making it a target for the condition.

news

Proteogenomic analysis offers insights into paediatric brain tumours

26 November 2020 | By Victoria Rees (Drug Target Review)

The first comprehensive survey of genomics, transcriptomics, global proteomics and phosphoproteomics has revealed insights into paediatric brain tumours.

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Novel inhibitor kills brain cancer cells missing ENO1 in mice, study shows

24 November 2020 | By Victoria Rees (Drug Target Review)

In pre-clinical studies, researchers have shown that a new therapy called POMHEX can destroy brain cancer cells that were missing one of two genes encoding the enolase enzyme.

Futuristic image - DNA stand with scissors about to cut it - idea of CRISPR gene editing

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CRISPR used to eliminate cancers caused by fusion genes

9 October 2020 | By Hannah Balfour (Drug Target Review)

Using CRISPR to cut out fusion genes, scientists were able to specifically induce cancer cell death in murine models of sarcoma and leukaemia.

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Researchers launch a collaborative brain metastases research platform

9 July 2020 | By Hannah Balfour (Drug Target Review)

The Brain Metastasis Cell Lines Panel compiles research from various international institutions on the numerous brain metastasis cell lines that have been developed, in hopes collaboration will expedite research and drug development.

woman undergoing radiation for brain cancer

news

Drug could prevent cognitive decline associated with brain tumour radiation

16 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers demonstrated NSPP completely prevented cognitive decline in mice treated with radiation for patient-derived glioblastomas.

cartoon image of a brain with a large red ball inside representing a tumour

news

ABCC4 transporter could be a novel target for paediatric medulloblastoma treatments

2 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers demonstrated that ABCC4 is essential to signalling in the SHH subgroup of medulloblastomas and when expression was reduced in mice, the tumours shrank.

red blood cells and platelets mixed together

news

Method to make integrin receptor-targeting drugs safer in future presented in study

5 February 2020 | By Hannah Balfour (Drug Target Review)

Research into the structure of the drug-integrin complex has enabled the creation of drugs which inhibit integrin as effectively as currently used compounds, without causing excessive bleeding.

news

Organoids produced to help develop paediatric brain tumour treatments

30 January 2020 | By Hannah Balfour (Drug Target Review)

Scientists have produced hundreds of organoids which they say could be produced on a large-scale as a low-cost tissue model to help research and test new medulloblastoma therapies.

news

Brain cancer model developed to study glioblastoma

30 January 2020 | By Rachael Harper (Drug Target Review)

Researchers have used stem cells, CRISPR and gene sequencing technology to create the basis of a new brain cancer model that could offer opportunities for drug discovery.

news

3D tissue models of brain tumours created in brain-mimicking environment

11 October 2019 | By Rachael Harper (Drug Target Review)

A new platform has the potential to better understand what dictates the invasive behaviour of brain tumours.

news

Researchers explain how lymphoma cells metastasise to the brain

17 September 2019 | By Rachael Harper (Drug Target Review)

Chronic inflammatory processes in ageing brains lead to lymphoma cells that have entered the brain tissue being retained.

news

Research helps to show how neural stem cells are activated

10 June 2019 | By Drug Target Review

A new study shows promise for future neural stem cell therapies in replacing cells lost through disease or injury.

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Brain cancer