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Alzheimer's

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Blood-brain barrier role in Alzheimer’s patients revealed by tissue model

13 August 2019 | By Rachael Harper (Drug Target Review)

A new study has found that damage caused by Alzheimer's allows toxins to enter the brain, further harming neurons.

article

Encouraging drug discovery and therapeutic targets for dementia

26 July 2019 | By Victoria Rees (Drug Target Review)

A review has been published by experts in neurodegeneration research, detailing six ways to improve dementia research. This article investigates one of these suggestions, focusing on how we can improve drug target identification.

news

Crystals mapped to advance treatments for stroke, diabetes and dementia

5 July 2019 | By Drug Target Review

Researchers haved mapped the crystal structure of a protein to find out how a drug latches onto it.

news

Potential drug target for Alzheimer’s identified

27 June 2019 | By Drug Target Review

New research has identified an enzyme which causes degradation of dendritic spines, pointing to a drug target for Alzheimer’s.

news

Neurofilament light chains detect Alzheimer’s damage before symptoms

22 January 2019 | By Drug Target Review

A simple blood test reliably detects signs of brain damage in people on the path to developing Alzheimer's disease...

news

Nuclear tracers help assess new drugs for neurodegenerative diseases

21 January 2019 | By Dr Zara Kassam (Drug Target Review)

New nuclear medicine tracers could help medical researchers find a cure for Alzheimer's and other neurodegenerative diseases.

news

New tools accurately illuminates intracellular phase separation

30 November 2018 | By Drug Target Review

Researchers have made discoveries about the formation of cellular components called membraneless organelles and the key role these organelles play in cells...

news

MRI scans shows promise in predicting dementia

23 November 2018 | By Drug Target Review

Brain changes evident in scans before memory, cognitive decline...

news

New information on the pathological mechanisms of Alzheimer’s disease

21 November 2018 | By Drug Target Review

Researchers have indicated that the accumulation of pathological tau triggers a safety valve mechanism in the otherwise well-regulated cell membranes...

news

Protein sequencing method could transform biological research

24 October 2018 | By Drug Target Review

A team of researchers have demonstrated a new way to sequence proteins that are much more sensitive than existing technology, identifying individual protein molecules rather than requiring millions of molecules at a time

news

Immunotherapy targeting blood protein fibrin

16 October 2018 | By Iqra Farooq (Drug Target Review)

Targeting the fibrin protein could ensure that fibrin leaking through the blood-brain barrier does not cause inflammation or disease in the brain...

news

Scientists create map of brain region linked to Alzheimer’s disease

8 October 2018 | By Drug Target Review

Scientists have mapped areas of the brain that are linked to Alzheimer's disease to deliver genetically-targeted drugs to specific neurons...

news

Cryo-EM shows structure of TRPM2

25 September 2018 | By Iqra Farooq (Drug Target Review)

The structure of the protein TRPM2, a possible drug target, has been revealed for the first time by researchers at Van Andel Research Institute...

news

The molecular link between ageing and neurodegeneration

28 August 2018 | By Drug Target Review

Researchers have described the discovery of a molecular link between ageing and a major genetic cause of both ALS and FTD...

news

Study suggests viral connection to Alzheimer’s disease

25 July 2018 | By Drug Target Review

A first-of-its-kind study implicates another culprit in the path to Alzheimer's disease: the presence of viruses in the brain...

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Alzheimer's