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Omics-informed drug target discovery in combating emerging infectious diseases

7 December 2018 | By Pushpanathan Muthuirulan

The catastrophic consequences of ever-increasing rates of death from infectious diseases demands new experimental strategies for drug target selection and drug design. Over the last decade, the pharmaceutical industry has been wounded by several issues including failure of drug-development programmes, burgeoning cost of drug development, increasing regulatory control, lack of…

Harmonizing drug-target binding data analytics on a single platform

Webinar highlights: Harmonising drug-target binding data analytics on a single platform

7 December 2018 | By PerkinElmer

Harmonising drug-target binding data analytics looks at building a single, integrated software platform for a future pharma research and development digital ecosystem. This webinar, sponsored by PerkinElmer, outlined the fundamentals of a design process where an experimental analytics data workflow was integrated into a more seamlessly interactive digital platform.

Webinar highlights: Recent advances in diagnostics and treatments – from small molecules to cellular therapies

7 December 2018 | By Bio-Techne

The webinar presented an overview of the pre-clinical milestones, the current status of the global drug pipeline and a description of a number of novel drugs undergoing clinical trials.

Leena Mol Thuruthippalli Senior Product Manager – Protein & Cell Analysis, Thermo Fisher Scientific

Expert view: Three-dimensional cell cultures as predictive tools in early drug discovery

6 December 2018 | By Leena Mol Thuruthippalli (Senior Product Manager – Protein & Cell Analysis at Thermo Fisher Scientific)

Three-dimensional cell cultures (spheroids, organoids) are becoming widely used as a new predictive tool in early drug discovery. The use of 3D cell cultures is believed to provide a more physiologically relevant response than monolayer (2D) cell cultures because they closely mimic the extracellular matrix and cell-cell interactions that occur…

Expert view: Challenges in drug discovery screening

6 December 2018 | By Steven Jarvis (Scientific Director - Global Strategic Accounts at Merck)

The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.

Webinar highlights: Cell-based and biochemical high-throughput screening in 1536-well plates

5 December 2018 | By BMG Labtech GmbH

The Small Molecule Screening Facility (SMSF) at the University of Wisconsin Madison is a comprehensive high-throughput screening (HTS) centre where researchers have investigated antibiotic-resistant bacterial infections and screening for protein-protein interactions using HTS methods.

Michael Kowalski, Global Project Manager at Beckman Coulter

Expert view: High-throughput screening – make an impact by removing barriers

5 December 2018 | By Michael Kowalski (Global Project Manager at Beckman Coulter)

For drug discovery and biomarker research, screening campaigns are employed to identify potential new treatments for diseases and to answer questions that remain unknown in the scientific community.

PAINS management: an open source model to eliminate nuisance compounds

4 December 2018 | By Stephen J. Capuzzi and David C. Morris (Eshelman School of Pharmacy - University of North Carolina Chapel Hill)

High-throughput screening (HTS) technologies have enabled the routine testing of millions of compounds towards the identification of novel ‘hit’ molecules for therapeutic targets. Oftentimes in this drug discovery process, however, compounds that show promising activity in primary screens show no activity during subsequent hit qualification or progression efforts.

Application Notes supplement 2018

4 December 2018 | By Drug Target Review

Researchers are always looking more effective and efficient ways of making their work more successful. In this supplement, some of our commercial partners share their data, detailing the application of their technology.

Webinar preview: Compliance with data integrity and computerised system validations

4 December 2018 | By PerkinElmer

Data integrity and computerised system validations (CSV) have become an area of increased scrutiny for regulatory agencies over the last several years. Understanding how the agencies view data integrity is critical for laboratories to maintain complete compliance.

Self-delivering RNAi: paving the way for a new class of cancer immunotherapies

4 December 2018 | By Geert Cauwenbergh

Earlier this year, the National Cancer Institute published its annual report to the nation on the status of cancer stating that there will be nearly 1.8 million new cases of cancer in 2018.1 New therapies have developed over time to improve cancer patient outcomes, including antibody immunotherapies targeting immune checkpoints,…

Stefan Duhr, CEO, NanoTemper Technologies

Expert view: Tackling drug discovery inefficiencies requires diverse libraries, technologies with broader applicability and actionable insights

4 December 2018 | By Stefan Duhr (CEO at NanoTemperTechnologies)

Inefficiencies in drug discovery are hard to ignore when despite ever-increasing investment in pharmaceutical research and development, the number of new drugs approved by the US Food and Drug Administration (FDA) remains low.

Under the microscope: CROs and microplate reader requirements

4 December 2018 | By BMG Labtech GmbH

Contract Research Organisations rely on microplate readers for effective hit discovery. Ian Waddell, of Charles River Laboratories, explains what his needs are.

Hit-to-Lead In-Depth Focus 2018

4 December 2018 | By Drug Target Review

This In-Depth Focus examines our understanding of the comprehensive and complex innate immune system, to develop novel treatments and an open source model to eliminate nuisance compounds

Screening In-Depth Focus 2018

3 December 2018 | By Drug Target Review

This In-Depth Focus looks at a high-throughput approach for measuring intracellular ATP levels to access compound-mediated cellular toxicity, the role of drug transporters in phenotypic screening, and how to leverage the power of HTS in the new and rapidly evolving collaborative drug discovery landscape.

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